4302-78-7Relevant academic research and scientific papers
Benzamide-4-sulfonamides are effective human carbonic anhydrase I, II, VII, and IX inhibitors
Abdoli, Morteza,Bozdag, Murat,Angeli, Andrea,Supuran, Claudiu T.
, (2018)
A series of benzamides incorporating 4-sulfamoyl moieties were obtained by reacting 4-sulfamoyl benzoic acid with primary and secondary amines and amino acids. These sulfonamides were investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA,
Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives
Gitto, Rosaria,De Luca, Laura,Mancuso, Francesca,Del Prete, Sonia,Vullo, Daniela,Supuran, Claudiu T.,Capasso, Clemente
, p. 1186 - 1192 (2019)
A series of sixteen benzenesulfonamide derivatives has been synthesised and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki value
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety
Buemi, Maria Rosa,Di Fiore, Anna,De Luca, Laura,Angeli, Andrea,Mancuso, Francesca,Ferro, Stefania,Monti, Simona Maria,Buonanno, Martina,Russo, Emilio,De Sarro, Giovanbattista,De Simone, Giuseppina,Supuran, Claudiu T.,Gitto, Rosaria
, p. 443 - 452 (2018/12/13)
Guided by the crystal structure of 4-(3,4-dihydroquinolin-1(2H)-ylcarbonyl)benzenesulfonamide 3 in complex with hCA II (PDB code 4Z0Q), a novel series of cycloalkylamino-1-carbonylbenzenesulfonamides was designed and synthesized. Thus, we replaced the qui
