43021-97-2

Usage

Uses

Used in Paints and Coatings Industry:
1-(2-Methoxyphenyl)-2-propanone oxime is used as a stabilizer and anti-skinning agent for paints, varnishes, and printing inks to prevent the formation of a skin or crust on the surface, ensuring a uniform and consistent application.
Used in Metalworking Fluids:
In the metalworking industry, 1-(2-Methoxyphenyl)-2-propanone oxime is utilized as a corrosion inhibitor, protecting metal surfaces from unwanted chemical or electrochemical reactions that could lead to degradation or damage.
Used in Adhesives and Sealants:
1-(2-Methoxyphenyl)-2-propanone oxime also serves as a curing agent in certain adhesives and sealants, contributing to the hardening and strengthening process of these materials for various bonding and sealing applications.
Additionally, 1-(2-Methoxyphenyl)-2-propanone oxime has been investigated for its potential neuroprotective and antioxidant properties, indicating possible future applications in the pharmaceutical or healthcare sector. However, it is important to note that exposure to 1-(2-Methoxyphenyl)-2-propanone oxime should be limited due to its potential to cause irritation to the skin, eyes, and respiratory system, and that prolonged or high-level exposure may lead to adverse health effects.

Upstream product

• 5211-62-1 1-(2-methoxyphenyl)propan-2-one 
• 6306-34-9 1-(2-methoxyphenyl)-2-nitropropene 

Downstream Products

• 1132758-25-8 (Z)-N-(1-(2-methoxyphenyl)prop-1-en-2-yl)acetamide 
• 1071023-32-9 (E)-N-(1-(2-methoxyphenyl)prop-1-en-2-yl)acetamide 

Relevant academic research and scientific papers

Copper-Catalyzed Aza-Sonogashira Cross-Coupling To Form Ynimines: Development and Application to the Synthesis of Heterocycles

Nitrogen-substituted alkynes, such as ynamines and ynamides, are versatile synthetic building blocks. Ynimines bearing additional nucleophilic and electrophilic centers relative to ynamines and ynamides are expected to have high synthetic potential. However, their chemical reactivity remains unexplored owing mainly to the lack of synthetic accessibility. We report herein a versatile copper-catalyzed synthesis of ynimines from readily available O-acetyl ketoximes and terminal alkynes. A wide range of O-acetyl ketoximes derived from diaryl ketones, aryl alkyl ketones and dialkyl ketones underwent cross-coupling with a diverse set of terminal alkynes to afford the ynimines in good to excellent yields. An unprecedented [5+1] heteroannulation reaction exploiting the reactivity of the ynimine generated in situ was subsequently developed for the synthesis of medicinally important heterocycles, including isoquinolines, azaindoles, azabenzofurans, azabenzothiophenes and carbolines.

Practical syntheses of N-acetyl (E)-β-arylenamides

A facile and practical method for the preparation of (E)-β- arylenamides [(E)-N-(1-arylprop-1-en-2-yl]acetamides] has been developed by reductive acetylation of the corresponding oximes with iron(II) acetate as the reducing reagent. Employment of hexamethylphosphoramide as the solvent was found to be critical for the high E/Z selectivity. The methodology has been applied in efficient syntheses of a key chiral intermediate of tamsulosin by asymmetric hydrogenation. Georg Thieme Verlag Stuttgart . New York.