43024-16-4Relevant academic research and scientific papers
Synthesis of pyrazolo[1,5-α]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold
Brizzi, Antonella,Corelli, Federico,Gianibbi, Beatrice,Mugnaini, Claudia,Pagli, Carlotta,Paolino, Marco,Pasculini, Livia
, (2021/10/30)
Reaction of 3-amino-1H-pyrazole-4-carbonitrile with 2,4-pentanedione yielded 5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-carbonitrile, which was easily and efficiently transformed into a small library of amido derivatives. This procedure opens the way to new compounds potentially endowed with interesting biological activities.
Synthesis of 1,3-substituted indoles, 2,4,6-substituted-s-triazines and 4,5-substituted pyrazoles as possible antifilarial agents
Chauhan, P. M. S.,Chatterjee, R. K.
, p. 32 - 37 (2007/10/02)
The synthesis of a series of 1,3-substituted indoles (6-11), 2,4,6-substituted s-triazines (12-18) and 4,5-substituted pyrazoles (21-27) has been carried out.These compounds (6-11, 12-18 and 21-27) have been tested for their antifilarial activity against L. carinii and B. malayi at a dose of 30 mg/kg * 5 days.The compounds 16 and 17 show 75percent and 70percent microfilaricidal activity respectively against L. carinii while the latter exhibits 85percent microfilaricidal and 50percent adulticidal action against B. malayi in Mastomys at 200mg/kg p.o. * 5 days.
SYNTHESIS OF SUBSTITUTED PYRAZOLO PYRIMIDINES
Deeb, Ali,El-Mobayed, Medhat,Essawy, Abd A.,El-Hamid, Adel Abd,El-Hamid, Atef Abd
, p. 303 - 309 (2007/10/02)
The reaction of 3-amino-4-cyanopyrazole (1) with ethyl acetoacetate, acetyl acetone, and ethyl cyanoacetate give pyrazolopyrimidine derivatives 2, 4, and 7 respectively. Compound 2 reacts with phosphorous oxychloride to give the corresponding 7-chl
PREPARATION AND CHARACTERIZATION OF PYRAZOLOPYRIMIDINES
Maquestiau, A.,Taghret, H.,Eynde, J.-J. vanden
, p. 131 - 136 (2007/10/02)
1-Phenyl-1,3-butadione readily reacts with 3(5)-amino-1H-pyrazoles to yield mixtures of pyrazolopyrimidines which are identified by 1H nmr.Selective preparation of 5-methyl-7-phenylpyrazolopyrimidines can be achieved when 3-amino-1-phenyl-2-
SYNTHESIS OF SUBSTITUTED PYRAZOLOPYRIMIDINES
Deeb, A.,El-Mobayed, M.,Hamid, A. Abdel,Hamid, A. Abdel
, p. 449 - 455 (2007/10/02)
The reaction of 3-amino-4-cyanopyrazole 1 with ethyl acetoacetate, acetylacetone and ethyl cyanoacetate yielded pyrazolopyrimidine derivatives 2, 4 and 7, respectively.Other members of this ring system resulted from the reaction of 1 with arylidene
3 Substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines, 3',5' cyclic AMP phosphodiesterase inhibitors. 1
Novinson,Hanson,Dimmitt,Simon,Robins,O'Brien
, p. 645 - 648 (2007/10/05)
A series of 3 substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines were synthesized and evaluated for their ability to inhibit the enzyme 3',5' cyclic AMP phosphodiesterase that was isolated and purified from rabbit kidney, rabbit lung, and beef heart. The 3 bromo, 3 chloro, 3 iodo, and 3 acetyl derivatives were found to be more potent than theophylline in their ability to inhibit these 3',5' cAMP phosphodiesterases.
