43024-19-7Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS. I. REACTIONS OF o-AMINO-CARBOXAMIDE WITH β-DIKETONES: SYNTHESIS OF IMIDAZOPYRIMIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES
Chern, Ji-Wang,Lee, Chung-Chi,Liaw, Yen-Chywan,Wang, Andrew H.-J.
, p. 1133 - 1145 (2007/10/02)
Treatment of 5-aminoimidazole-4-carboxamide hydrochloride (1) and 5-aminopyrazole-4-carboxamide hemisulfate (2) with β-diketones furnished 2,4-disubstituted imidazopyrimidine-8-carboxamide (7) and 5,7-disubstituted pyrazolopyrimidine-3-carbo
3 Substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines, 3',5' cyclic AMP phosphodiesterase inhibitors. 1
Novinson,Hanson,Dimmitt,Simon,Robins,O'Brien
, p. 645 - 648 (2007/10/05)
A series of 3 substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines were synthesized and evaluated for their ability to inhibit the enzyme 3',5' cyclic AMP phosphodiesterase that was isolated and purified from rabbit kidney, rabbit lung, and beef heart. The 3 bromo, 3 chloro, 3 iodo, and 3 acetyl derivatives were found to be more potent than theophylline in their ability to inhibit these 3',5' cAMP phosphodiesterases.
