43024-70-0

Basic information

• Product Name: Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate
• Synonyms: Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate;7-Chloropyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester
• CAS NO: 43024-70-0
• Molecular Formula: C9H8ClN3O2
• Molecular Weight: 225.634
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 43024-70-0.mol

Chemical Properties

• Appearance: /
• Density: 1.47
• Refractive Index: 1.648
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate(43024-70-0)
• EPA Substance Registry System: Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate(43024-70-0)

Safety Data

• Hazardous Substances Data: 43024-70-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate is used as a compound of interest in pharmaceutical research for its potential biological activity and therapeutic properties. Its unique structure may contribute to the development of new drugs or treatments for various medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate serves as a key intermediate or building block in the creation of more complex molecules with specific applications in medicine, agriculture, or other industries.
Used in Material Science:
Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate may also find applications in material science, where its unique structure could be utilized to develop new materials with specific properties, such as improved stability or reactivity.
Used in Environmental Chemistry:
Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate could be employed in environmental chemistry for the development of processes or products aimed at environmental protection or remediation.
Used in Analytical Chemistry:
Ethyl 7-chloropyrazolo[1,5-a]pyrimidine-6-carboxylate may also be used in analytical chemistry for the development of new methods or techniques for detecting, measuring, or analyzing other substances, given its unique structural features and potential reactivity.

InChI:InChI=1/C9H8ClN3O2/c1-2-15-9(14)6-5-11-7-3-4-12-13(7)8(6)10/h3-5H,2H2,1H3

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 29274-17-7 diethyl 2-((1H-pyrazol-5-ylamino)methylene)malonate 
• 43024-61-9 6-ethoxycarbonyl-7-hydroxypyrazolo<1,5-a>pyrimidine 

Downstream Products

• 1333214-16-6 3-(N-tert-butylsulfamoyl)-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylic acid 
• 1333213-51-6 N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]cyclopropanecarboxamide 
• 1333214-17-7 7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide 
• 1333214-15-5 N-tert-butyl-7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide 
• 1333214-14-4 ethyl 3-(N-tert-butylsulfamoyl)-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 1333214-13-3 6-ethoxycarbonyl-7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-3-sulfonic acid 
• 1333213-67-4 N-[7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidin-3-ylsulfonyl]acetamide 
• 1333214-12-2 ethyl 7-(4-fluoro-2-methylphenylamino)pyrazolo[1,5-a]pyrimidine-6-carboxylate 
• 1022920-59-7 Pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 
• 43024-89-1 3-bromo-7-(carboxymethyl-amino)-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester 

Relevant articles and documents

CHEMOKINE RECEPTOR ACTIVITY REGULATOR

The invention provides a chemokine receptor activity modulator containing a pyrazolopyrimidine derivative represented by the formula (I) wherein R1, R2, R3, and R4 are as described herein.

PYRAZOLOPYRIMIDINE DERIVATIVE

The present invention provides a pyrazolopyrimidine derivative represented by formula (I) {wherein R1 represents -NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom, ar

3-Aminocarbonyl-substituted fused pyrazolo-derivatives as protein kinase modulators

The present invention relates to pyrazolo[1,5-a]pyrimidine-3-carboxylic acid compounds of formula I or pharmaceutically acceptable salts thereof and their use for the treatment of protein kinase modulation responsive diseases.

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.

Synthesis and Enzymic Activity of 6-Carbethoxy- and 6-Ethoxy-3,7-disubstituted-pyrazolopyrimidines and Related Derivatives as Adenosine Cyclic 3',5'-Phosphate Phosphodiesterase Inhibitors

A number of 3,7-disubstituted 6-carbethoxypyrazolopyrimidines and 3,7-disubstituted 6-ethoxypyrazolopyrimidines have been prepared and evaluated as adenosine cyclic 3',5'-phosphate (cAMP) phosphodiesterase (PDE) inhibitors vs. the low Km enzyme isolated from beef heart, rabbit lung, and kidney preparations.The results were found to be between 0.5 to 13 times as potent as theophylline as inhibitors of PDE, depending on the tissue source.A number of these PDE inhibitors exhibited significant physiological effects in different animal systems, suggesting it should be possible to obtain selective PDE inhibition in various tissues.Several of these heterocycles were found superior to adenosine in inhibiting ADP-induced platelet aggregation in vitro.