IWR-1/IWR1 is a chemical compound that functions as an inhibitor of the Wnt signaling pathway by specifically targeting the protein tankyrase. It has demonstrated effectiveness in blocking tankyrase activity, which plays a crucial role in the regulation of the Wnt pathway, a key mechanism for cell proliferation and differentiation. By inhibiting tankyrase, IWR-1/IWR1 can modulate Wnt signaling, making it a promising compound for research and potential therapeutic applications in cancer and regenerative medicine.
430429-02-0
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Basic information
- Product Name: IWR-1/IWR1
- Synonyms: IWR-1/IWR1;4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinylbenzamide
- CAS NO:430429-02-0
- Molecular Formula: C25H19N3O3
- Molecular Weight: 409.43666
- EINECS: N/A
- Product Categories: N/A
- Mol File: 430429-02-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 643.9±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: Tan solid
- Density: 1.425±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 11.88±0.43(Predicted)
- CAS DataBase Reference: IWR-1/IWR1(CAS DataBase Reference)
- NIST Chemistry Reference: IWR-1/IWR1(430429-02-0)
- EPA Substance Registry System: IWR-1/IWR1(430429-02-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 430429-02-0(Hazardous Substances Data)
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430429-02-0 Usage
Uses
Used in Cancer Research:IWR-1/IWR1 is used as a research tool for studying the Wnt signaling pathway in cancer. Its ability to inhibit tankyrase activity allows researchers to investigate the role of the Wnt pathway in tumor growth and progression, as well as to explore potential therapeutic strategies for various types of cancer.
Used in Regenerative Medicine:
IWR-1/IWR1 is used as a modulator of stem cell differentiation in regenerative medicine. By controlling Wnt signaling, it has the potential to enhance the differentiation of stem cells into specific cell types, which can be applied in tissue repair and regeneration.
Used in Drug Development:
IWR-1/IWR1 is used as a lead compound in the development of new drugs targeting the Wnt signaling pathway. Its inhibitory effect on tankyrase makes it a candidate for further optimization and development into a therapeutic agent for treating diseases associated with dysregulated Wnt signaling, such as cancer and degenerative disorders.
Overall, IWR-1/IWR1 is a versatile compound with potential applications in various fields, including cancer research, regenerative medicine, and drug development, due to its ability to modulate the Wnt signaling pathway by inhibiting tankyrase.
Check Digit Verification of cas no
The CAS Registry Mumber 430429-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,0,4,2 and 9 respectively; the second part has 2 digits, 0 and 2 respectively.Calculate Digit Verification of CAS Registry Number 430429-02:
(8*4)+(7*3)+(6*0)+(5*4)+(4*2)+(3*9)+(2*0)+(1*2)=110
110 % 10 = 0
So 430429-02-0 is a valid CAS Registry Number.
430429-02-0Upstream product
430429-02-0Downstream Products
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IWR-1/IWR1
