430436-52-5

Upstream product

• 430436-51-4 1-{6-[2-(tert-butyldimethylsilanoxy)-6-methoxyphenyl]-2,2,4-trimethyl-1,2-dihydroquinolin-5-yl}but-3-en-1-ol 
• 239070-97-4 2,5-dihydro-10-methoxy-5-oxo-2,2,4-trimethyl-1H-[1]benzopyrano [3,4-f]quinoline 
• 239071-11-5 6-[2-(tert-butyldimethylsilanoxy)-6-methyloxyphenyl]=2,2,4-trimethyl-1,2-dihydroquinoline-5-carbaldehyde 
• 430436-50-3 {6-[2-(tert-butyldimethylsilanoxy)-6-methoxyphenyl]-2,2,4-trimethyl-1,2-dihydroxyquinolin-5-yl}methanol 
• 430436-49-0 6-[2-(tert-butyldimethylsilanoxy)-6-methoxyphenyl]-2,2,4-trimethyl-1,2-dihydroquinoline-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Process for the preparation of chiral glucocorticoid receptor agents

The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.

Asymmetric synthesis of A-240610.0 via a new atropselective approach for axially chiral biaryls with chirality transfer

A new approach for atropselective preparation of axially chiral biaryl was developed. This process proceeded through a chirality transfer from a stereogenic center of a secondary alcohol to the stereogenic axis via regioselective intramolecular silyl grou