43044-76-4Relevant articles and documents
The model of 1,3-dipolar cycloaddition reaction of 4,5-dihydro-1H-imidazole 3-oxide derivatives with alkynes
Popov, Sergey A.,Romanenko, Galina V.,Reznikov, Vladimir A.
, p. 30 - 39 (2008/03/18)
The influence of solvents and different structural factors on the rate of 1,3-dipolar cycloaddition reaction of the 4,5-dihydro-1H-imidazole 3-oxide derivatives with alkynes have been studied. Nitrones and alkynes have been ranged by their relative activity in this reaction. Using the DFT calculation with the triple zets basis set, the energy profile of the reaction has been plotted, and the structures and energy characteristics of the transition states have been determined. The mechanism of this reaction has been shown to be concerted and asynchronous. The validity of the used computational approach for the detailed investigation of 1,3-dipolar cycloaddition of nitrones has been demonstrated.
New Synthesis of β-Lactams Based on Nitrone Cycloaddition to Nitroalkenes
Padwa, Albert,Koehler, Konrad F.,Rodriguez, Augusto
, p. 282 - 288 (2007/10/02)
Heating a sample of the major 5-nitro-substituted isoxazolidine isomer obtained from the reaction of a C-phenyl-N-alkylnitrone with trans-1-cyano-2-nitroethylene in methanol resulted in ring contraction and formation of 4-phenyl-3-cyano-N-alkyl-2-azetidin
