430454-17-4

Basic information

• Product Name: 2-(4-bromo-2-chlorophenoxy)-N-isopropylacetamide
• Synonyms: 2-(4-bromo-2-chlorophenoxy)-N-isopropylacetamide;2-(4-bromo-2-chlorophenoxy)-N-(propan-2-yl)acetamide
• CAS NO: 430454-17-4
• Molecular Formula: C11H13BrClNO2
• Molecular Weight: 306.58342
• Mol File: 430454-17-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-bromo-2-chlorophenoxy)-N-isopropylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromo-2-chlorophenoxy)-N-isopropylacetamide(430454-17-4)
• EPA Substance Registry System: 2-(4-bromo-2-chlorophenoxy)-N-isopropylacetamide(430454-17-4)

Safety Data

• Hazardous Substances Data: 430454-17-4(Hazardous Substances Data)

Upstream product

• 2895-21-8 2-chloro-N-isopropylacetamide 
• 3964-56-5 4-bromo-2-chlorophenol 

Relevant articles and documents

Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors

PI3K/Akt/mTOR signaling pathway plays an important role in cancer cell growth and survival. In this study, a new class of molecules with skeleton of 4-phenyl-2H-benzo[b] [1,4]oxazin-3(4H)-one were designed and synthesized targeting this pathway. Bioassays showed that, among all the molecules, 8d-1 was a pan-class I PI3K/mTOR inhibitor with an IC50 of 0.63 nM against PI3Kα. In a wide panel of protein kinases assays, no off-target interactions of 8d-1 were identified. 8d-1 was orally available, and displayed favorable pharmacokinetic parameters in mice (oral bioavailability of 24.1%). In addition, 8d-1 demonstrated significant efficiency in Hela/A549 tumor xenograft models (TGI of 87.7% at dose of 50 mg/kg in Hela model) without causing significant weight loss and toxicity during 30 days treatment. Based on the bioassays, compound 8d-1 could be used as an anti-cancer drug candidate.