430460-97-2

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 430461-97-5 (3R,8R,8aR)-8-(4-methoxyphenyl)-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 430461-29-3 (3R,8S,8aS)-8-(4-methoxyphenyl)-8a-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 450416-84-9 (2S,3R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine 
• 430461-59-9 (2R,3S)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-(4-methoxyphenyl)-2-methylpiperidine 
• 450416-88-3 (2S,3R)-3-(4-methoxyphenyl)-2-methyl-1-propylpiperidine 
• 450416-78-1 (2R,3S)-3-(4-methoxyphenyl)-2-methyl-1-propylpiperidine 

Relevant academic research and scientific papers

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

Cyclodehydration of racemic γ-aryl-δ-oxoesters with (R)- or (S)-phenylglycinol stereoselectively affords bicyclic δ-lactams, in a process that involves a dynamic kinetic resolution. Subsequent reduction of these lactams leads to enantiopure 3-arylpiperidines. Starting from racemic aldehyde esters, this short sequence has been applied to the synthesis of (R)-3-phenylpiperidine and the antipsychotic drug (-)-3-PPP (an (S)-3-arylpiperidine), whereas starting from racemic ketone esters enantiopure cis-2-alkyl-3-arylpiperidines are prepared.