43076-44-4 Usage
General Description
The chemical "1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride" is a complex compound that consists of multiple functional groups. It contains a piperidinium cation, a p-tert-butylbenzoyl group, a hydroxybenzhydryl group, and a chloride anion. The p-tert-butylbenzoyl group is attached to a propyl chain, while the hydroxybenzhydryl group is attached to the piperidinium cation. 1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride can be used in various chemical reactions and applications due to the diverse functional groups it contains. The chloride anion provides a counter ion to balance the charge of the cation, and the overall compound may exhibit unique properties and reactivity due to its complex structure.
Check Digit Verification of cas no
The CAS Registry Mumber 43076-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,7 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 43076-44:
(7*4)+(6*3)+(5*0)+(4*7)+(3*6)+(2*4)+(1*4)=104
104 % 10 = 4
So 43076-44-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H39NO2.ClH/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28;/h4-9,11-14,16-19,29,35H,10,15,20-24H2,1-3H3;1H
43076-44-4Relevant articles and documents
Synthesis of terfenadine
Carr,Meyer
, p. 1157 - 1159 (2007/10/02)
The synthesis of α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebut anol (terfenadine, RMI 9918, Triludan, Teldane, resp.) is described. A limited structure-activity analysis of the central nervous system-mediated side effects of this compound and related analogs is made relative to the antipsychotic agent, haloperidol. Modification of the piperidine 4-position substituents of haloperidol to give a 4-(α,α-diphenylmethyanol) moiety has conveyed histamine H1-antagonism to the antipsychotic agent, haloperidol. Structural changes of this fluorobutyrophenone have progressively reduced and finally eliminated centrally-mediated side effects. The result of this exercise is terfenadine, a preferred antihistamine, potent and selective in antagonizing histamine H1-receptor-mediated responses but lacking the usual side effect profile of known histamine H1-receptor antagonists.
