43076-44-4 Usage
Uses
Used in Pharmaceutical Industry:
1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride is used as a pharmaceutical intermediate for the synthesis of various drugs due to its complex structure and diverse functional groups, which can be utilized in the development of new therapeutic agents.
Used in Chemical Reactions:
In the field of organic chemistry, 1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride serves as a versatile reactant in various chemical reactions, such as condensation, substitution, and rearrangement reactions, due to the presence of multiple reactive sites within its structure.
Used in Material Science:
1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride can be employed in the development of novel materials with unique properties, such as polymers, coatings, or sensors, owing to its complex structure and the potential for self-assembly or interaction with other molecules.
Used in Analytical Chemistry:
1-[3-(p-tert-butylbenzoyl)propyl]-4-(hydroxybenzhydryl)piperidinium chloride can be utilized as a reagent or standard in analytical chemistry for the detection, quantification, or separation of other compounds, taking advantage of its unique chemical properties and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 43076-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,0,7 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 43076-44:
(7*4)+(6*3)+(5*0)+(4*7)+(3*6)+(2*4)+(1*4)=104
104 % 10 = 4
So 43076-44-4 is a valid CAS Registry Number.
InChI:InChI=1/C32H39NO2.ClH/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28;/h4-9,11-14,16-19,29,35H,10,15,20-24H2,1-3H3;1H
43076-44-4Relevant academic research and scientific papers
Synthesis of terfenadine
Carr,Meyer
, p. 1157 - 1159 (2007/10/02)
The synthesis of α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebut anol (terfenadine, RMI 9918, Triludan, Teldane, resp.) is described. A limited structure-activity analysis of the central nervous system-mediated side effects of this compound and related analogs is made relative to the antipsychotic agent, haloperidol. Modification of the piperidine 4-position substituents of haloperidol to give a 4-(α,α-diphenylmethyanol) moiety has conveyed histamine H1-antagonism to the antipsychotic agent, haloperidol. Structural changes of this fluorobutyrophenone have progressively reduced and finally eliminated centrally-mediated side effects. The result of this exercise is terfenadine, a preferred antihistamine, potent and selective in antagonizing histamine H1-receptor-mediated responses but lacking the usual side effect profile of known histamine H1-receptor antagonists.
Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
-
, (2008/06/13)
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula SPC1 Wherein R represents hydrogen or hydroxy; R1 represents hydrogen; or R and R1 taken together form a
