43088-00-2

Basic information

• Product Name: 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE
• Synonyms: 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE;AKOS BB-8016;ASISCHEM T31096
• CAS NO: 43088-00-2
• Molecular Formula: C₁₃H₉ClN₂S
• Molecular Weight: 260.74
• Mol File: 43088-00-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE(43088-00-2)
• EPA Substance Registry System: 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE(43088-00-2)

Safety Data

• Hazardous Substances Data: 43088-00-2(Hazardous Substances Data)

Usage

General Description

4-Benzothiazol-2-yl-3-chloro-phenylamine, also known as CB-1, is a compound containing a benzothiazole ring and a chlorophenyl group. It is a chemical intermediate used in the synthesis of pharmaceuticals, dyes, and agrochemicals. 4-BENZOTHIAZOL-2-YL-3-CHLORO-PHENYLAMINE has shown antimicrobial and antitumor activities, making it a potential candidate for drug development. It is also used in the production of fluorescent dyes and pigments due to its fluorescent properties. 4-Benzothiazol-2-yl-3-chloro-phenylamine is a versatile chemical with a wide range of potential applications in various industries.

Upstream product

• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 137-07-5 2-amino-benzenethiol 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 174536-60-8 2-(2-Chloro-4-nitrophenyl)benzothiazole 

Downstream Products

• 1073610-33-9 4β-[4-(1,3-benzothiazole-2-yl)-3-chloroanilino]-4-desoxypodophyllotoxin 
• 1073610-34-0 4'-O-demethyl-4β-[4-(1,3-benzothiazole-2-yl)-3-chloroanilino]-4-desoxypodophyllotoxin 

Relevant articles and documents

Design, synthesis, biological evaluation and in silico studies of few novel 2-substituted benzothiazole derivatives as potential EGFR inhibitors

Background: There is a great unmet medical need for new anticancer small molecule therapeutics. Exhaustive literature review suggests that benzothiazole derivatives have good potential to exhibit anticancer activity. Compounds that inhibit the kinase acti

An efficient one-pot synthesis of benzothiazolo-4β-anilino- podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity

An efficient one-pot iodination methodology for the synthesis of benzothiazolo-4β-anilino-podophyllotoxin (5a-h) and benzothiazolo-4β- anilino-4-O-demethylepipodophyllotoxin (6a-h) congeners has been successfully developed by using zirconium tetrachloride

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Based on an (aminoaryl)benzothiazole quinazoline hit structure for kinase inhibition, a systematic optimization program resulted in a lead structure allowing for inhibitory activities in cellular phosphorylation assays in the low nanomolar range.