43091-89-0

Basic information

• Product Name: Benzonitrile, 2-isothiocyanato-4,5-dimethoxy-
• CAS NO: 43091-89-0
• Molecular Formula: C10H8N2O2S
• Molecular Weight: 220.252
• Mol File: 43091-89-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-isothiocyanato-4,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-isothiocyanato-4,5-dimethoxy-(43091-89-0)
• EPA Substance Registry System: Benzonitrile, 2-isothiocyanato-4,5-dimethoxy-(43091-89-0)

Safety Data

• Hazardous Substances Data: 43091-89-0(Hazardous Substances Data)

Upstream product

• 169778-81-8 2-(cyanothioformamido)-4,5-dimethoxybenzonitrile 
• 463-71-8 thiophosgene 
• 26961-27-3 2-amino-4,5-dimethoxybenzonitrile 

Downstream Products

• 86543-00-2 4-Methyl-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide 
• 86543-06-8 N-(3,4-dimethoxy-6-cyanophenyl)-N',N'-(3-carboxamidopentamethylene)thiourea 
• 86543-04-6 1-(2-Cyano-4,5-dimethoxy-phenylthiocarbamoyl)-piperidine-4-carboxylic acid ethyl ester 
• 67817-59-8 Methyl N-(3,4-Dimethoxy-6-cyanophenyl)-<4-(2-furoyl)piperazin-1-yl>thioformamidate 
• 19237-84-4 prazosin hydrochloride 
• 80030-56-4 1-{[(Z)-2-Cyano-4,5-dimethoxy-phenylimino]-methylsulfanyl-methyl}-piperidine-3-carboxylic acid ethyl ester 
• 80030-55-3 1-{[(Z)-2-Cyano-4,5-dimethoxy-phenylimino]-methylsulfanyl-methyl}-piperidine-3-carboxylic acid ethyl ester 
• 23673-00-9 2-(4-Benzyl-piperidin-1-yl)-6,7-dimethoxy-quinazolin-4-ylamine; hydrochloride 
• 80030-52-0 N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(pyrrolidine-1-carbonyl)-piperidine-1-carboximidothioic acid methyl ester 
• 80024-64-2 1-{[(Z)-2-Cyano-4,5-dimethoxy-phenylimino]-methylsulfanyl-methyl}-piperidine-4-carboxylic acid ethyl ester 
• 86543-26-2 4-Benzyl-N-(2-cyano-4,5-dimethoxy-phenyl)-piperidine-1-carboximidothioic acid methyl ester 
• 80030-57-5 N-(3,4-dimethoxy-6-cyanophenyl)-N',N'-(3-carboxamidopentamethylene)-S-methylisothiourea 
• 86543-29-5 N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-ethyl)-piperidine-1-carboximidothioic acid methyl ester 
• 86543-25-1 N-(2-Cyano-4,5-dimethoxy-phenyl)-4-methyl-piperidine-1-carboximidothioic acid methyl ester 

Relevant articles and documents

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors

Novel triazoloquinazolines have been found as phosphodiesterase 10A (PDE10A) inhibitors. Structure-activity studies improved the initial micromolar potency which was found in the lead compound by a 100-fold identifying 5-(1H-benzoimidazol-2-ylmethylsulfan

New syntheses of aryl isothiocyanates

Primary aromatic amines are readily converted into arylimino-1,2,3-dithiazoles 2 and the derived cyanothioformanilides 6, both of which are rapidly cleaved by ethylmagnesium bromide in hot THF to give the corresponding isothiocyanates. The transformation 2→6→ArNCS can be performed as a 'one-pot' operation. The imines 2 are also converted, more slowly, into the isothiocyanates by sodium hydride in hot THF, via the cyanothioformanilides 6. Conversion of the anilides 6 into isothiocyanates is much faster under microwave irradiation in 2,6-lutidine. Mechanisms are proposed for these reactions.

New practical synthesis of prazosin

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