431-23-2

Basic information

• Product Name: 3,3,3-Trifluoro-2-Methylpropan-1-ol
• Synonyms: 3,3,3-Trifluoro-2-Methylpropan-1-ol
• CAS NO: 431-23-2
• Molecular Formula: C4H7F3O
• Molecular Weight: 128.0929896
• Mol File: 431-23-2.mol

Chemical Properties

• Boiling Point: 104.047°C at 760 mmHg
• Flash Point: 54.35°C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 17.289mmHg at 25°C
• Refractive Index: 1.335
• Storage Temp.: 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: 3,3,3-Trifluoro-2-Methylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-Trifluoro-2-Methylpropan-1-ol(431-23-2)
• EPA Substance Registry System: 3,3,3-Trifluoro-2-Methylpropan-1-ol(431-23-2)

Safety Data

• RIDADR: 1993
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 431-23-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis Industry:
3,3,3-Trifluoro-2-Methylpropan-1-ol is used as a solvent for facilitating various chemical reactions in the synthesis of different organic compounds. Its unique properties allow it to dissolve a wide range of substances, making it a valuable asset in the chemical synthesis process.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,3,3-Trifluoro-2-Methylpropan-1-ol serves as an intermediate in the synthesis of various pharmaceutical compounds. Its ability to participate in multiple chemical reactions contributes to the development of new drugs and medications.
Used in Research and Development:
3,3,3-Trifluoro-2-Methylpropan-1-ol is utilized in research and development settings to explore its potential applications and properties. Scientists and researchers use 3,3,3-Trifluoro-2-Methylpropan-1-ol to investigate its reactivity, stability, and interactions with other chemicals, which can lead to the discovery of new applications and advancements in the field of chemistry.
Used in Industrial Applications:
3,3,3-Trifluoro-2-Methylpropan-1-ol is employed in various industrial applications, such as the production of specialty chemicals, coatings, and adhesives. Its versatility as a solvent and intermediate allows it to be incorporated into the manufacturing processes of a wide range of products.

InChI:InChI=1/C4H7F3O/c1-3(2-8)4(5,6)7/h3,8H,2H2,1H3

Upstream product

• 2314-97-8 iodotrifluoromethane 
• 5689-83-8 4-methyl-[1,3,2]dioxathiolane 2,2-dioxide 
• 2794-71-0 3,3,3-trifluoro-2-methylpropan-1-amine hydrochloride 
• 381-97-5 (2RS)-3,3,3-trifluoro-2-methylpropanoic acid 
• 339-17-3 2-(trifluoromethyl)propionic acid methyl ester 

Relevant articles and documents

PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, R7, R8, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Process for trifluoromethylation of sulfates

The subject invention relates to a process for the trifluoromethylation of sulfates, including cyclic and acyclic sulfates. The subject invention further pertains to the compounds produced by the trifluoromethylation of sulfates.

Novel Nucleophilic Trifluoromethylation of Vicinal Diol Cyclic Sulfates

(Matrix Presented) A novel method for highly regioselective and stereospecific nucleophilic trifluoromethylation of vicinal diol cyclic sulfates, using the reagent derived from reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented.

Deamination Reactions, 43 - The Effect of Trifluoromethyl Groups on the Reactivity of Aliphatic Diazonium Ions and Carbocations

Various trifluoroalkanamines (9, 26, 35, 38, 45, 56, and 67) have been prepared and diazotized (water, pH 3.5) to probe the effect of trifluoromethyl groups on the reactivity of aliphatic diazonium ions.The product distributions reveal that α-CF3 groups enhance inverting displacement and enforce rearrangement (hydride shifts) separating the positive charge from CF3.Migrations of the positive charge from the β- to the γ-position are less strongly promoted than those from α to β.Enhancement factors of ca. 15 (α -> β) and 4 (β -> γ) may be derived by comparison with analogous alkanediazonium ions.The positive charge does not migrate in the reverse direction (β -> α) except for minor amounts of a pinacolic rearrangement (68 -> 7).A migration of the positive charge from γ to β has been detected with 36 but a tenfold decrease as compared to the analogous butanediazonium ion 37 is indicated.All observations are reasonably explained in terms of the relative stabilities of the intermediate trifluoroalkyl cations.