431040-68-5Relevant academic research and scientific papers
Highly enantioselective hydrosilylation of aromatic alkenes
Jensen, Jakob F.,Svendsen, Bo Y.,La Cour, Thomas V.,Pedersen, Henriette L.,Johannsen, Mogens
, p. 4558 - 4559 (2007/10/03)
Currently, the most effective and economic way to convert an alkene into an optically active alcohol is the two-step sequence: hydrosilylation/oxidation. Much work has been devoted to elucidating effective catalysts for this process, but hitherto only one effective and highly stereoselective process has been available. Herein we present a novel catalytic system for the asymmetric hydrosilylation of aromatic alkenes, giving the products in high yields and with the highest enantioselectivity (up to 99% ee) ever observed for this reaction. The reaction works efficiently for a variety of substituted aromatic alkenes, giving access after Tamao oxidation to almost optically pure benzylic alcohols in high yields. Copyright
Synthesis of (β-N-sulfonylaminoalkyl)phosphines and their use in palladium-mediated asymmetric synthesis
Sakuraba,Okada,Morimoto,Achiwa
, p. 927 - 934 (2007/10/02)
A series of (β-N-sulfonylaminoalkyl)phosphine ligands has been developed and employed for asymmetric palladium-catalyzed hydrosilylation and Heck-type hydroarylation, affording up to 72% ee and 90% yield.
