431064-89-0Relevant academic research and scientific papers
Synthesis of some novel 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones and their nucleosides as potential therapeutic agents
Singh, Girwar,Singh, Gajendra,Yadav, Ashok K.,Mishra
, p. 107 - 116 (2000)
Some newer 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones were synthesized by the condensation of 2-amino-3-cyano-4,6-disubstituted pyridines with phenylisothiocyanate. The nucleosides viz., 4-imino-3,5,7-trisubstituted-1-(2,3,5-tri-O-
Synthesis and antimicrobial evaluation of some new pyrido[2, 3-d]pyrimidines and their ribofuranosides
Singh, Girwar,Singh, Gajendra,Yadav, Ashok K.,Mishra
, p. 430 - 432 (2007/10/03)
4-Amino-5, 7-disubstituted 3- d] pyrimidin-2(1 H)-ones 3 and 5, 7-disubstituted-pyrido[2.3-d]-pyrimidine-2-4-(1H, 2H dithiones 4 have been synthesized by the condensation of 2-amino-3-cyano-4, 6-disubstituted-pyridines 2 with urea and carbon disulphide, respectively. Compounds 2 have been synthesized by condensing chalcones 1 with malononitrile and ammonium acetate. The condensation of trimethylsilyl derivatives of compounds 3 with β-D-ribofuranose 1-acetate-2, 3, 5-tribenzoate in the presence of SnCl4 furnish the nucleosides, viz, 4-amino-5, 7-disubstituted-1-(2, 3, 5-tri-O-benzoyl-α-D-ribofuranosyl)pyrido[2, 3-d]pyrimidin-2(1H)-ones 5. Compounds 3-5 have been screened for their antibacterial and antifungal activities.
