431069-31-7

Upstream product

• 79-16-3 N-methyl-acetamide 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 431069-51-1 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-benzylcarbamoyl-ethyl ester 
• 431069-60-2 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-benzylcarbamoyl-2-phenyl-ethyl ester 
• 431069-89-5 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-2-methyl-1-((S)-1-phenyl-ethylcarbamoyl)-propyl ester 
• 431069-95-3 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-2-methyl-1-((R)-1-phenyl-ethylcarbamoyl)-propyl ester 
• 431069-55-5 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-benzylcarbamoyl-3-methyl-butyl ester 
• 431069-99-7 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-2-methyl-1-(1-methyl-1-phenyl-ethylcarbamoyl)-propyl ester 
• 431070-05-2 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-(benzhydryl-carbamoyl)-2-methyl-propyl ester 
• 431070-17-6 (S)-1-[(1,1-diphenylmethyl)carbamoyl]-2-methyl-propyl (1R,4S,5R)-5-benzyl-oxy-1,2-dimethyl-3-oxo-7-oxa-2-aza-bicyclo[2.2.1]heptane-4-carboxylate 
• 431069-68-0 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-benzylcarbamoyl-2,2-dimethyl-propyl ester 
• 431069-47-5 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-benzylcarbamoyl-2-methyl-propyl ester 
• 431069-73-7 (S)-2-[3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionyloxy]-3-methyl-butyric acid benzyl ester 
• 431876-75-4 3-(Acetyl-methyl-amino)-2-diazo-3-oxo-propionic acid (S)-1-(4-benzyloxy-benzylcarbamoyl)-2-methyl-propyl ester 

Relevant academic research and scientific papers

Modular evolution of a chiral auxiliary for the 1,3-dipolar cycloaddition of isomuenchnones with vinyl ethers.

[reaction: see text]. The 1,3-dipolar cycloaddition reaction has long been recognized as a powerful methodology in organic synthesis. More recently, this reaction has become a popular manifold for the construction of chemical diversity. Herein, we report the development of a chiral template for the facially selective cycloaddition of isomuenchnones, a common class of 1,3-dipoles. The modular format of the asymmetric unit allowed a systematic optimization of selectivity. In addition, the chiral auxiliary was removed through an unusually facile ester aminolysis.