4313-72-8Relevant academic research and scientific papers
Diastereoselective specificity for the hydrolysis of dipeptide esters in aqueous media
Ueoka, Ryuichi,Goto, Kouichi,Tanoue, Osamu,Miki, Atsushi,Yoshimitsu, Shinya,Imamura, Chikara,Ihara, Yasuji,Murakami, Yukito
, p. 73 - 74 (2007/10/03)
The diastereoselectivity for the hydrolysis of p-methoxycarbonylphenyl N-(benzyloxycarbonyl)-D(L)-phenylalanyl-L-leucinate in aqueous solution was inverted by changing concentrations of the substrates or the reaction temperature. The monomer-aggregate transition operated on the LL-substrate, which was suggested by the spectroscopic measurements, seems to be responsible for such behavior.
Efficient 1,4-Asymetric Induction Utilizing Electrostatic Interaction between Ligand and Substrate in the Asymmetric Hydrogenation of Didehydrodipeptides
Yamagishi, Takamichi,Ikeda, Satoru,Yatagai, Masanobu,Yamaguchi, Motowo,Hida, Mitsuhiko
, p. 1787 - 1790 (2007/10/02)
Electrostatic interaction between the amino group of the achiral 3-dimethylaminopropylidenebismethylenebis(diphenylphosphine) (1) and the carboxy group of the substrate enable an effective 1,4-asymmetric induction in the RhI-catalysed hydrogenation of didehydrodipeptides, to give (S,S)-or (R,R)-products selectively.The selectivity reached up to 94percent diastereoisomeric excess with acetyl didehydrodipeptides and 92percent with benzyloxycarbonyl substrates.
