43141-68-0Relevant articles and documents
Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes
Cerqueira, Nuno M. F. S. A.,Rama Raju, B.,Gon?alves, M. Sameiro T.,Leit?o, Maria Inês P. S.,Sousa, Maria Jo?o
, (2020/03/24)
Four new benzo[a]phenoxazinium chlorides with combinations of chloride, ethyl ester and methyl as terminals of the amino substituents were synthesized. These compounds were characterized and their optical properties were studied in absolute dry ethanol an
BENZOPHENOXAZINE DERIVATIVES FOR DIAGNOSIS OF NEOPLASIA OR INFECTION
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Paragraph 0060-0061, (2019/10/29)
The present disclosure is related to the synthesis and applications of a benzo[a]phenoxazine. It displays good photophysical properties, such as high molar extinction coefficient, good fluorescence quantum yield and solubility in water. The present invent
Effect of alkoxy side chain length on the solid-state fluorescence behaviour of bisazomethine dyes possessing dipropylamino terminal group
Yu, Hyung-Wook,Kim, Byung-Soon,Matsumoto, Shinya
, p. 131 - 139 (2016/09/02)
A study was conducted on the optical properties of alkoxy-substituted bisazomethine dyes possessing a dipropylamino terminal group in solution and the solid state. All of the derivatives had similar optical properties in chloroform solution, showing weak
Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents
Gurrapu, Shirisha,Jonnalagadda, Sravan K.,Alam, Mohammad A.,Ronayne, Conor T.,Nelson, Grady L.,Solano, Lucas N.,Lueth, Erica A.,Drewes, Lester R.,Mereddy, Venkatram R.
, p. 3282 - 3286 (2016/07/12)
Novel N,N-dialkyl carboxy coumarins have been synthesized as potential anticancer agents via inhibition of monocarboxylate transporter 1 (MCT1). These coumarin carboxylic acids have been evaluated for their in vitro MCT1 inhibition, MTT cancer cell viability, bidirectional Caco-2 cell permeability, and stability in human and liver microsomes. These results indicate that one of the lead candidate compounds 4a has good absorption, metabolic stability, and a low drug efflux ratio. Systemic toxicity studies with lead compound 4a in healthy mice demonstrate that this inhibitor is well tolerated based on zero animal mortality and normal body weight gains compared to the control group. In vivo tumor growth inhibition studies in mice show that the candidate compound 4a exhibits significant single agent activity in MCT1 expressing GL261-luc2 syngraft model but doesn't show significant activity in MCT4 expressing MDA-MB-231 xenograft model, indicating the selectivity of 4a for MCT1 expressing tumors.
Synthesis and photophysical studies of new benzo[a]phenoxazinium chlorides as potential antifungal agents
Leit?o, M. Inês P.S.,Raju, B. Rama,Naik, Sarala,Coutinho, Paulo J.G.,Sousa, Maria Jo?o,Gon?alves, M. Sameiro T.
supporting information, p. 3936 - 3941 (2016/08/09)
A set of four new benzo[a]phenoxazinium chlorides possessing ethyl, propyl, decyl and tetradecyl groups at the 9-amino function of the heterocycle along with a propyl group at the 5-amino position was efficiently synthesized. These compounds displayed fluorescence with maximum emission wavelengths of 673 and 685?nm, in anhydrous ethanol and water. All the benzo[a]phenoxazines were evaluated against the yeast Saccharomyces cerevisiae in a broth microdilution assay. It was found that their antifungal activity depended on the variation in the lengths of the aliphatic chains. The highest MIC activity of 1.56?μM was obtained for compound 7 comprising a di-alkylated propyl substituent at 9-amino position and a propyl chain at the 5-amino position of the heterocycle core.
Thermotropic behaviour, self-assembly and photophysical properties of a series of squaraines
Qaddoura, Maher A.,Belfield, Kevin D.,Tongwa, Paul,Desanto, Jessica E.,Timofeeva, Tatiana V.,Heiney, Paul A.
scheme or table, p. 731 - 742 (2012/03/11)
A series of squaraine dyes, based on 2,4-bis[4-(N,N-di-n-alkylamino)-2- hydroxyphenyl] squaraine including ethyl, propyl, butyl, pentyl, hexyl and heptyl derivatives, were synthesised by condensation of the corresponding 4-(N,N-di-n-alkylamino)-2-hydroxyp
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives
Ge, Jian-Feng,Arai, Chika,Kaiser, Marcel,Wittlin, Sergio,Brun, Reto,Ihara, Masataka
supporting information; scheme or table, p. 3654 - 3658 (2009/04/06)
3,7-Bis(dialkylamino)phenoxazinium salts were synthesized and evaluated for in vitro activities against Plasmodium falciparum, Trypanosoma cruzi, T. brucei rhodesiense, and Leishmania donovani. Notably, the compounds showed potent antiprotozoal activities, especially against P. falciparum and T. cruzi. The compounds with alkyl side chains less than three carbons in length possessed good activities with high selective indices.
