43156-00-9

Upstream product

• 1635-61-6 5-chloro-2-nitroaniline 
• 150-76-5 4-methoxy-phenol 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 43156-26-9 4-(p-methoxyphenoxy)-1,2-phenylendiamine 
• 43155-61-9 methyl 5-<(p-methoxy)phenoxy>-2-benzimidazolecarbamate 

Relevant academic research and scientific papers

New benzimidazole-2-urea derivates as tubulin inhibitors

Emerging drug resistance and other drawbacks limit tubulin inhibitors' therapeutic applications and developing novel tubulin inhibitors still attracts intensive efforts. We describe the discovery and structure-activity relationship study of a series of benzimidazole-2-urea derivatives as novel β tubulin inhibitors. The representative compound 6o potently suppressed the proliferation of a panel of human cancer cells (NCI-H460, Colo205, K562, A431, HepG2, Hela, MDA-MB-435S) with IC50 values of 0.040, 0.050, 0.006, 0.026, 1.774, 0.452 and 0.052 μM, respectively. Compound 6o obviously inhibited NCI-H460 spindles formation and induced cell cycle arrest at G2/M phase at 0.10 μM. Computational study suggested that 6o interacts with β tubulin in a novel binding mode. Our results suggested that benzimidazole-2-urea derivatives might be promising tubulin inhibitors with novel binding mode for further development.

Sulfonamide-based compounds as protein tyrosine kinase inhibitors

Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Synthesis and spectral properties of methyl 5-[(o-, m-, and p-r)- phenoxy]-2-benzimidazolecarbamate

The preparation of eleven novel methyl 5-[(o-, m-, p-R)-phenoxy-2- benzimidazolecarbamates with possible pharmacological activity as anthelmintics is described. The structure of all products was corroborated by it, 1H-nmr, 13C-nmr and mass spectra.

Anthelmintically active 2-carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers

2-Carbalkoxy-amino-benzimidazole-5(6)-phenyl ethers of the formula (I) SPC1 in which R1 represents alkyl of 1 to 4 carbon atoms, R2 and R3 represent, independently of each other, hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms or carbalkoxy of 1 to 4 carbon atoms in the alkoxy group, R4 represents hydrogen or chlorine and X represents oxygen or sulfur, useful as anthelmintics.