43157-32-0Relevant articles and documents
Synthesis, metabolism and in vitro cytotoxicity studies on novel lavendamycin antitumor agents
Cai, Wen,Hassani, Mary,Karki, Rajesh,Walter, Ervin D.,Koelsch, Katherine H.,Seradj, Hassan,Lineswala, Jayana P.,Mirzaei, Hamid,York, Jeremy S.,Olang, Fatemeh,Sedighi, Minoo,Lucas, Jennifer S.,Eads, Thomas J.,Rose, Anthony S.,Charkhzarrin, Sahba,Hermann, Nicholas G.,Beall, Howard D.,Behforouz, Mohammad
experimental part, p. 1899 - 1909 (2010/05/18)
A series of lavendamycin analogues with two, three or four substituents at the C-6, C-7 N, C-2′, C-3′ and C-11′ positions were synthesized via short and efficient methods and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor agents. The compounds were prepared through Pictet-Spengler condensation of the desired 2-formylquinoline-5,8-diones with the required tryptophans followed by further needed transformations. Metabolism and toxicity studies demonstrated that the best substrates for NQO1 were also the most selectively toxic to NQO1-rich tumor cells compared to NQO1-deficient tumor cells.
