4316-73-8Relevant articles and documents
SYSTEM FOR CONTINUOUS MANUFACTURING OF SODIUM SARCOSINATE
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Paragraph 0009-0014, (2017/11/01)
The invention relates to a system for continuous manufacturing of sodium sarcosinate. The system for continuous manufacturing of sodium sarcosinate in high pressure apparatus includes steps of : (a) mixing sodium chloroacetate solution with methylamine solution. (b)amination of mixed solution of sodium chloroacetate and methylamine under high pressure to obtain product of amination.(c)separating product of amination to obtain sodium sarcosinate. System for continuous manufacturing of sodium sarcosinate comprises: amination of mixed solution of sodium chloroacetate and methylamine under high pressure with continuous module to simplify process and improve reaction efficiency.
Process for the preparation of creatine water (by machine translation)
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Paragraph 0041; 0042, (2016/10/07)
The invention discloses a preparation method of creatine monohydrate, and provides the preparation method of the creatine monohydrate. The method comprises the following steps: step 1, carrying out a nucleophilic substitution reaction on a glycolonitrile aqueous solution and a methylamine aqueous solution for 1 to 6 hours at a temperature of 10 DEG C to 40 DEG C so as to generate methylamino acetonitrile; step 2, carrying out a hydrolysis reaction on the methylamino acetonitrile reaction liquid obtained in the step 1 for 2 to 6 hours at the temperature of 60 DEG C to 80 DEG C and in the presence of sodium hydroxide so as to obtain a sodium sarcosinate aqueous solution; step 3, regulating pH to 9 to 12 and carrying out a condensation reaction on the sodium sarcosinate aqueous solution and the cyanamide for 1 to 6 hours at the temperature of 50 DEG C to 90 DEG C so as to obtain the creatine monohydrate. The method is moderate in reaction condition, less in byproduct, high in yield and suitable for industrial production. The structure of the creatine monohydrate is as shown in the specification.