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4316-73-8

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  • Sodium sarcosinate CAS 4316-73-8 Sodium 2-(methylamino)acetate CAS no 4316-73-8 N-Methylglycine monosodium salt

    Cas No: 4316-73-8

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4316-73-8 Usage

Uses

Different sources of media describe the Uses of 4316-73-8 differently. You can refer to the following data:
1. Intermediate, stabilizer for diazonium salts, chelating agent.
2. Sarcosine Sodium Salt is a salt of Sarcosine (S140500) which has been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 4316-73-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,1 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4316-73:
(6*4)+(5*3)+(4*1)+(3*6)+(2*7)+(1*3)=78
78 % 10 = 8
So 4316-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C3H7NO2.Na/c1-4-2-3(5)6;/h4H,2H2,1H3,(H,5,6);/q;+1/p-1

4316-73-8 Well-known Company Product Price

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  • TCI America

  • (M0256)  Sarcosine Sodium Salt (ca. 40% in Water)  

  • 4316-73-8

  • 25mL

  • 290.00CNY

  • Detail
  • TCI America

  • (M0256)  Sarcosine Sodium Salt (ca. 40% in Water)  

  • 4316-73-8

  • 100mL

  • 595.00CNY

  • Detail
  • TCI America

  • (M0256)  Sarcosine Sodium Salt (ca. 40% in Water)  

  • 4316-73-8

  • 500mL

  • 1,320.00CNY

  • Detail

4316-73-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Sodium 2-(methylamino)acetate

1.2 Other means of identification

Product number -
Other names (Methylamino)acetic acid sodium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:4316-73-8 SDS

4316-73-8Synthetic route

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

sodium sarcosinate
4316-73-8

sodium sarcosinate

Conditions
ConditionsYield
With sodium hydroxide; Cu/Ni Raney catalyst In water at 160℃; under 7500.75 Torr; for 4h;97.2%
With (6-di-tert-butylphosphinomethyl-2,2’-bipyridyl)Ru(CO)HCl; water; sodium hydroxide In 1,4-dioxane for 24h; Schlenk technique; Inert atmosphere; Glovebox; Reflux;> 99 %Spectr.
sarcosine
107-97-1

sarcosine

sodium sarcosinate
4316-73-8

sodium sarcosinate

Conditions
ConditionsYield
With ammonia; sodium
(methylamino)acetonitrile
5616-32-0

(methylamino)acetonitrile

sodium sarcosinate
4316-73-8

sodium sarcosinate

Conditions
ConditionsYield
With sodium hydroxide at 75℃; for 4h; Temperature; Large scale;
sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

methylamine
74-89-5

methylamine

sodium sarcosinate
4316-73-8

sodium sarcosinate

Conditions
ConditionsYield
at 10 - 200℃; under 836.056 - 228015 Torr; Flow reactor;
tris(hydroxymethyl)phosphine
2767-80-8

tris(hydroxymethyl)phosphine

sodium sarcosinate
4316-73-8

sodium sarcosinate

tris(N-methyl-N-sodiumcarboxylatomethylaminomethyl)phosphine

tris(N-methyl-N-sodiumcarboxylatomethylaminomethyl)phosphine

Conditions
ConditionsYield
In water at 20℃; for 1h; Condensation;99%
sodium sarcosinate
4316-73-8

sodium sarcosinate

chloroacetic acid
79-11-8

chloroacetic acid

sodium methyliminodiacetate
71160-37-7

sodium methyliminodiacetate

Conditions
ConditionsYield
Stage #1: sodium sarcosinate; chloroacetic acid With sodium iodide In water at 20℃; for 1h; Large scale;
Stage #2: With sodium hydroxide In water at 55 - 90℃; for 4.5h; pH=8.5 - 9; Large scale;
98%
sodium sarcosinate
4316-73-8

sodium sarcosinate

oleic acid chloride

oleic acid chloride

N-oleoylsarcosine
110-25-8

N-oleoylsarcosine

Conditions
ConditionsYield
With water; sodium hydroxide In toluene at 30℃; for 1h; Solvent;97.8%
2M-NaOH

2M-NaOH

sarcosine
107-97-1

sarcosine

di-o-tolyl carbonate
617-09-4

di-o-tolyl carbonate

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-methoxycarbonyl-N-methyl-glycine
116714-27-3

N-methoxycarbonyl-N-methyl-glycine

Conditions
ConditionsYield
With hydrogenchloride90.5%
calcium cyanamide
156-62-7

calcium cyanamide

sodium sarcosinate
4316-73-8

sodium sarcosinate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
With phosphoric acid; sulfuric acid86%
phosphoric acid75%
sulfuric acid
2,6-bis-(bromomethyl)pyridine
7703-74-4

2,6-bis-(bromomethyl)pyridine

sodium sarcosinate
4316-73-8

sodium sarcosinate

N,N'-<(pyridine-2,6-diyl)bis(methylene)>bis
146448-83-1

N,N'-<(pyridine-2,6-diyl)bis(methylene)>bis

Conditions
ConditionsYield
With sodium hydroxide In methanol for 13h; Heating;85%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

sodium sarcosinate
4316-73-8

sodium sarcosinate

sarcosine-N-carboxyanhydride
5840-76-6

sarcosine-N-carboxyanhydride

Conditions
ConditionsYield
With 4-methyl-morpholine In water; acetonitrile at 20℃; Flow reactor;81%
sodium sarcosinate
4316-73-8

sodium sarcosinate

4-[(3-bromophenyl)-amino]-6-fluoropyrido[3,4-d]pyrimidine
171179-03-6

4-[(3-bromophenyl)-amino]-6-fluoropyrido[3,4-d]pyrimidine

{[4-(3-Bromo-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-methyl-amino}-acetic acid

{[4-(3-Bromo-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-methyl-amino}-acetic acid

Conditions
ConditionsYield
In ethanol at 95℃; for 48h;79%
CYANAMID
420-04-2

CYANAMID

sodium sarcosinate
4316-73-8

sodium sarcosinate

Creatinine
57-00-1

Creatinine

Conditions
ConditionsYield
Stage #1: sodium sarcosinate With hydrogenchloride In water pH=9.6; Cooling;
Stage #2: CYANAMID In water at 75 - 80℃; for 3.5h;
76.2%
In 2-Methyl-1,2-propanediol75%
With carbon dioxide In water at 75℃; for 6h; pH=9 - 10;75%
With formic acid In tert-butyl methyl ether at 50℃; for 1h; pH=9.8;70%
With ammonium chloride68%
2,4,6-trinitrochlorobenzene
88-88-0

2,4,6-trinitrochlorobenzene

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-methyl-N-(2,4,6-trinitrophenyl)glycine
124052-31-9

N-methyl-N-(2,4,6-trinitrophenyl)glycine

Conditions
ConditionsYield
In methanol; water for 0.333333h;70%
Boc-Ser(Bn)-OH

Boc-Ser(Bn)-OH

sodium sarcosinate
4316-73-8

sodium sarcosinate

Boc-L-Ser(O-Bn)-Sar-OH

Boc-L-Ser(O-Bn)-Sar-OH

Conditions
ConditionsYield
Stage #1: Boc-Ser(Bn)-OH With 4-methyl-morpholine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In acetonitrile at 20℃; for 0.00138889h; Flow reactor;
Stage #2: sodium sarcosinate In water; acetonitrile at 20℃; for 0.00277778h; Flow reactor;
67%
sodium sarcosinate
4316-73-8

sodium sarcosinate

2-chloro-1,3,2-dioxaphospholan
822-39-9

2-chloro-1,3,2-dioxaphospholan

9-methyl-1,4,6-trioxa-9-aza-5λ5-phospha-spiro[4.4]nonan-7-one
63972-72-5

9-methyl-1,4,6-trioxa-9-aza-5λ5-phospha-spiro[4.4]nonan-7-one

sodium sarcosinate
4316-73-8

sodium sarcosinate

methyloxirane
75-56-9, 16033-71-9

methyloxirane

2-oxo-4,6-dimethyl-morpholine
18484-89-4

2-oxo-4,6-dimethyl-morpholine

Conditions
ConditionsYield
In water
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-acyl sarcosinate
97-78-9

N-acyl sarcosinate

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
With hydrogenchloride In hexane; water at 5 - 15℃; for 6h; pH=11 - 11.5; Temperature; pH-value;586 g
undecanoyl chloride
17746-05-3

undecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-methyl-N-undecanoyl-glycine
36461-64-0

N-methyl-N-undecanoyl-glycine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
n-tridecanoyl chloride
17746-06-4

n-tridecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-methyl-N-tridecanoyl-glycine
83871-14-1

N-methyl-N-tridecanoyl-glycine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
heptadecanoyl chloride
40480-10-2

heptadecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-heptadecanoyl-N-methyl-glycine
83871-15-2

N-heptadecanoyl-N-methyl-glycine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
sodium sarcosinate
4316-73-8

sodium sarcosinate

n-decanoyl chloride
112-13-0

n-decanoyl chloride

N-decanoyl sarcosine
2671-91-2

N-decanoyl sarcosine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
sodium sarcosinate
4316-73-8

sodium sarcosinate

tetradecanoyl chloride
112-64-1

tetradecanoyl chloride

N-tetradecanoylsarcosine
52558-73-3, 2421-31-0

N-tetradecanoylsarcosine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
sodium sarcosinate
4316-73-8

sodium sarcosinate

Stearoyl chloride
112-76-5

Stearoyl chloride

N-stearoyl sarcosine
142-48-3

N-stearoyl sarcosine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
sodium sarcosinate
4316-73-8

sodium sarcosinate

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

N-hexadecanoylsarcosine
2421-33-2

N-hexadecanoylsarcosine

Conditions
ConditionsYield
In water at 40 - 50℃; for 1h; pH 9.5-10.5;
With sodium hydroxide at 45℃; for 1h;
undec-10-enoyl chloride
38460-95-6

undec-10-enoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-undecylenoyl sarcosine

N-undecylenoyl sarcosine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide for 0.5h; Ambient temperature;
sodium allyloxide
20907-32-8

sodium allyloxide

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-methyl-N-<3-hydroxy-propyl>-glycine methyl ester

N-methyl-N-<3-hydroxy-propyl>-glycine methyl ester

Conditions
ConditionsYield
at 108℃; und Veresterung des Reaktionsprodukts mit methanol.HCl;
sarcosine
107-97-1

sarcosine

cis-Octadecenoic acid
112-80-1

cis-Octadecenoic acid

sodium sarcosinate
4316-73-8

sodium sarcosinate

N-oleoylsarcosine
110-25-8

N-oleoylsarcosine

Conditions
ConditionsYield
In water; isopropyl alcohol
Decyl-oxiran
2855-19-8

Decyl-oxiran

sodium sarcosinate
4316-73-8

sodium sarcosinate

isopropyl alcohol
67-63-0

isopropyl alcohol

A

C15H32O2

C15H32O2

B

C15H30NO3(1-)*Na(1+)

C15H30NO3(1-)*Na(1+)

C

dodecane-1,2-diol
1119-87-5

dodecane-1,2-diol

Conditions
ConditionsYield
at 70 - 82℃; for 5.5h;
CYANAMID
420-04-2

CYANAMID

sodium sarcosinate
4316-73-8

sodium sarcosinate

creatine monohydrate powder
6020-87-7

creatine monohydrate powder

Conditions
ConditionsYield
In water
With water at 20 - 80℃; for 1h; Temperature; Large scale;
erucic acid chloride
59044-32-5, 7459-29-2

erucic acid chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

C25H47NO3
133152-18-8

C25H47NO3

Conditions
ConditionsYield
With sodium hydroxide In water at 30 - 35℃; for 1h; pH=9 - 11;
n-dodecanoyl chloride
112-16-3

n-dodecanoyl chloride

sodium sarcosinate
4316-73-8

sodium sarcosinate

sodium N-lauroylsarcosinate
137-16-6

sodium N-lauroylsarcosinate

Conditions
ConditionsYield
In water at 10 - 30℃; for 5h; pH=10.3 - 10.6; Schotten-Baumann Reaction; Inert atmosphere;
With sodium hydroxide In water at 10 - 30℃; for 5h; pH=10.3 - 10.6; Inert atmosphere;

4316-73-8Relevant articles and documents

SYSTEM FOR CONTINUOUS MANUFACTURING OF SODIUM SARCOSINATE

-

Paragraph 0009-0014, (2017/11/01)

The invention relates to a system for continuous manufacturing of sodium sarcosinate. The system for continuous manufacturing of sodium sarcosinate in high pressure apparatus includes steps of : (a) mixing sodium chloroacetate solution with methylamine solution. (b)amination of mixed solution of sodium chloroacetate and methylamine under high pressure to obtain product of amination.(c)separating product of amination to obtain sodium sarcosinate. System for continuous manufacturing of sodium sarcosinate comprises: amination of mixed solution of sodium chloroacetate and methylamine under high pressure with continuous module to simplify process and improve reaction efficiency.

Process for the preparation of creatine water (by machine translation)

-

Paragraph 0041; 0042, (2016/10/07)

The invention discloses a preparation method of creatine monohydrate, and provides the preparation method of the creatine monohydrate. The method comprises the following steps: step 1, carrying out a nucleophilic substitution reaction on a glycolonitrile aqueous solution and a methylamine aqueous solution for 1 to 6 hours at a temperature of 10 DEG C to 40 DEG C so as to generate methylamino acetonitrile; step 2, carrying out a hydrolysis reaction on the methylamino acetonitrile reaction liquid obtained in the step 1 for 2 to 6 hours at the temperature of 60 DEG C to 80 DEG C and in the presence of sodium hydroxide so as to obtain a sodium sarcosinate aqueous solution; step 3, regulating pH to 9 to 12 and carrying out a condensation reaction on the sodium sarcosinate aqueous solution and the cyanamide for 1 to 6 hours at the temperature of 50 DEG C to 90 DEG C so as to obtain the creatine monohydrate. The method is moderate in reaction condition, less in byproduct, high in yield and suitable for industrial production. The structure of the creatine monohydrate is as shown in the specification.

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