43170-88-3 Usage
Uses
Used in Pharmaceutical Industry:
Diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate is used as an active pharmaceutical ingredient for the development of chemotherapy drugs. It is effective in the treatment of various types of cancer, including leukemia, breast cancer, and lung cancer, due to its ability to inhibit the production of folic acid in cancer cells, thereby slowing down their growth and division.
Used in Cancer Research:
In the field of cancer research, diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate serves as a valuable compound for studying the mechanisms of action of antifolate drugs. Its unique chemical structure and antifolate activity make it an important tool for understanding the molecular pathways involved in cancer cell growth and division, and for identifying potential targets for the development of novel cancer therapies.
Used in Drug Delivery Systems:
Diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate can be incorporated into drug delivery systems to improve the efficacy and bioavailability of chemotherapy drugs. By encapsulating diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate within nanoparticles or other carriers, researchers can enhance its delivery to cancer cells, reduce systemic side effects, and potentially overcome drug resistance in cancer treatment.
Overall, diethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate is a versatile and promising compound in the fight against cancer, with applications in the development of chemotherapy drugs, cancer research, and drug delivery systems. Its unique chemical structure and antifolate activity make it an important component in the ongoing efforts to improve cancer treatment outcomes and patient quality of life.
Check Digit Verification of cas no
The CAS Registry Mumber 43170-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,1,7 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 43170-88:
(7*4)+(6*3)+(5*1)+(4*7)+(3*0)+(2*8)+(1*8)=103
103 % 10 = 3
So 43170-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H30N8O5/c1-4-36-18(33)11-10-17(23(35)37-5-2)29-22(34)14-6-8-16(9-7-14)32(3)13-15-12-27-21-19(28-15)20(25)30-24(26)31-21/h6-9,12,17H,4-5,10-11,13H2,1-3H3,(H,29,34)(H4,25,26,27,30,31)/t17-/m0/s1
43170-88-3Relevant academic research and scientific papers
An algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations
Oliveira, Catiuscia P.,Venturini, Cristina G.,Donida, Bruna,Poletto, Fernanda S.,Guterres, Silvia S.,Pohlmann, Adriana R.
, p. 1141 - 1150 (2013/03/28)
Aqueous solutions of lipid-core nanocapsules are interesting drug delivery systems for passive drug targeting. In this study, we hypothesized that the drug distribution mechanisms in lipid-core nanocapsule formulations could be categorized into six different types. To experimentally determine the type of drug distribution in these formulations, we proposed the use of an algorithm as an innovative strategy. The approach is shown to be a valuable tool to optimize and select formulations intended for drug delivery. The best physico-chemical parameter in terms of predicting the type of distribution was the log D value. In conclusion, the use of the algorithm developed in this study represents a simple and rapid approach through which it was possible to experimentally determine the drug distribution in colloidal formulations for eight drug models.
