43197-28-0 Usage
Uses
Used in Pharmaceutical Synthesis:
1-(6-Bromo-1,3-benzodioxol-5-yl)-2-propanone is used as an intermediate in the synthesis of 2-Bromo Carbidopa (B682075), a derivative of Carbidopa (C175915). Carbidopa is a medication primarily used to treat Parkinson's disease by reducing the peripheral conversion of levodopa to dopamine, thereby increasing the availability of levodopa in the brain and improving its therapeutic effects.
In the synthesis of 2-Bromo Carbidopa, 1-(6-Bromo-1,3-benzodioxol-5-yl)-2-propanone acts as a key building block, contributing to the formation of the final product. This intermediate compound is essential for the development of new drugs and therapies that can potentially improve the treatment of various medical conditions, including Parkinson's disease.
Used in Research and Development:
1-(6-Bromo-1,3-benzodioxol-5-yl)-2-propanone is also utilized in research and development for the creation of novel compounds with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science. Its unique chemical structure allows for the exploration of new reactions and the synthesis of innovative molecules with diverse properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 43197-28-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,1,9 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 43197-28:
(7*4)+(6*3)+(5*1)+(4*9)+(3*7)+(2*2)+(1*8)=120
120 % 10 = 0
So 43197-28-0 is a valid CAS Registry Number.
43197-28-0Relevant academic research and scientific papers
Organocatalytic asymmetric synthesis of trans-1,3-disubstituted tetrahydroisoquinolines via a reductive amination/aza-michael sequence
Enders, Dieter,Liebich, Jens X.,Raabe, Gerhard
supporting information; experimental part, p. 9763 - 9766 (2010/10/21)
(Figure Presented) Benzothiazoline better than Hantzsch: A stereoselective Bronsted acid catalyzed reductive amination/aza-Michael approach towards the important class of tetrahydroisoquinolines is presented (see scheme). A biphenyl-substituted benzothiazoline is used as the reducing agent and leads to superior yields and enantiomeric excesses compared with the frequently used Hantzsch ester. The cyclization of the amine intermediate occurs smoothly with potassium tert-butoxide as the base and affords the trans-1,3-disubstituted tetrahydroisoquinolines.
