431981-97-4

Upstream product

• 439944-33-9 4-O-(2-methyl-2-butenyl)-3,5-diacetoxybenzoic acid methyl ester 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 99-24-1 methyl galloate 
• 20189-90-6 3,4,5-triacetoxy-benzoic acid methyl ester 

Downstream Products

• 439944-34-0 4-O-(2-methyl-2-butenyl)-3,5-dimethoxybenzoic acid methyl ester 

Relevant academic research and scientific papers

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.