Zopiclone N-oxide, also known as Eszopiclone impurity A, is a primary, active metabolite of zopiclone found in urine. It is derived from the parent drug, zopiclone, which is a non-benzodiazepine hypnotic used in the treatment of insomnia. Zopiclone N-oxide is characterized by its off-white to pale beige solid appearance.
43200-96-0
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Basic information
- Product Name: ZOPICLONE N-OXIDE
- Synonyms: ZOPICLONE N-OXIDE; RP 2975;1-Piperazine-carboxylic Acid 4-Methyl-4-oxide 6-(5-Chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5yl Ester;Zopiclone N-Oxide (Mixture of diastereomers);RP 29753;Zopiclone N-Oxide (Eszopiclone Impurity A) (Mixture of Diastereomers);Zopiclone N-Oxide (Eszopiclone Impurity A) ;4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester 4-oxide
- CAS NO:43200-96-0
- Molecular Formula: C17H17ClN6O4
- Molecular Weight: 404.81
- EINECS: 200-659-6
- Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Heterocycles;Impurities;Isotopically Labeled Pharmaceutical Reference Standard
- Mol File: 43200-96-0.mol
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Chemical Properties
- Melting Point: >140°C (dec.)
- Boiling Point: N/A
- Flash Point: 9℃
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer
- Solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated, Soni
- PKA: 4.92±0.20(Predicted)
- CAS DataBase Reference: ZOPICLONE N-OXIDE(CAS DataBase Reference)
- NIST Chemistry Reference: ZOPICLONE N-OXIDE(43200-96-0)
- EPA Substance Registry System: ZOPICLONE N-OXIDE(43200-96-0)
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Safety Data
- Hazard Codes: F,T
- Statements: 11-23/24/25-39/23/24/25
- Safety Statements: 7-16-36/37-45
- RIDADR: UN1230 - class 3 - PG 2 - Methanol
- WGK Germany: 1
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 43200-96-0(Hazardous Substances Data)
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43200-96-0 Usage
Uses
Used in Pharmaceutical Industry:Zopiclone N-oxide is used as a metabolite for understanding the metabolic pathways and pharmacokinetics of the parent drug, zopiclone. This knowledge aids in the development of more effective and safer medications for insomnia treatment.
Used in Quality Control:
Zopiclone N-oxide is used as a major pharmaceutical impurity (Eszopiclone impurity A) in the quality control process of zopiclone manufacturing. Monitoring and controlling the levels of this impurity ensure the safety and efficacy of the final drug product.
Used in Research and Development:
Zopiclone N-oxide serves as a valuable compound in research and development for studying the effects of zopiclone and its metabolites on the central nervous system. This research can lead to the discovery of new therapeutic approaches for insomnia and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 43200-96-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,3,2,0 and 0 respectively; the second part has 2 digits, 9 and 6 respectively.Calculate Digit Verification of CAS Registry Number 43200-96:
(7*4)+(6*3)+(5*2)+(4*0)+(3*0)+(2*9)+(1*6)=80
80 % 10 = 0
So 43200-96-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
43200-96-0 Well-known Company Product Price
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Sigma-Aldrich
(Z3001000) Zopiclone oxide European Pharmacopoeia (EP) Reference Standard
43200-96-0
Z3001000
1,880.19CNY
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USP
(1255861) Eszopiclone Related Compound A United States Pharmacopeia (USP) Reference Standard
43200-96-0
1255861-10MG
13,501.80CNY
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43200-96-0Downstream Products
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ZOPICLONE N-OXIDE
