432001-29-1Relevant academic research and scientific papers
Novel dihydropyrimidines as a potential new class of antitubercular agents
Trivedi, Amit R.,Bhuva, Vimal R.,Dholariya, Bipin H.,Dodiya, Dipti K.,Kataria, Vipul B.,Shah, Viresh H.
supporting information; experimental part, p. 6100 - 6102 (2010/11/18)
A small library of 30 dihydropyrimidines was synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol- 4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5 carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3, 4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent than isoniazid.
