432016-77-8Relevant academic research and scientific papers
W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway
Li, Ting,Lin, Guang-Yao,Zhong, Li,Zhou, Yan,Wang, Jia,Zhu, Yue,Feng, Yang,Cai, Xiao-Qing,Liu, Qing,Nosjean, Olivier,Boutin, Jean A,Renard, Pierre,Yang, De-Hua,Wang, Ming-Wei
, p. 1024 - 1037 (2017)
Recent evidence shows that high glucose levels recruit carbohydrate response element-binding protein, which binds the promoter of thioredoxin-interacting protein (txnip), thereby regulating its expression in β-cells. Overexpression of txnip not only induc
Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression
Zhong, Li,Liu, Qing,Ting, Yan Sie,Thien, Vun Yien,Binti Kalong, Nurwafa Syafiqah,Yang, Dehua,Wang, Ming-Wei
, p. 1998 - 2008 (2018/09/21)
Overexpression of thioredoxin-interacting protein (TXNIP) is associated with reduced insulin sensitivity and β-cell apoptosis. We have previously shown that W2476 inhibited high glucose-induced TXNIP expression at both mRNA and protein levels in INS-1E ce
COMPOUNDS FOR IMMUNOPOTENTIATION
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Page/Page column 156, (2010/02/15)
Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
