43219-09-6

Basic information

• Product Name: 1-(2-CHLOROETHYL)-4-PHENYLPIPERAZINE
• Synonyms: CHEMBRDG-BB 4017037;AKOS BB-5421;1-(2-CHLOROETHYL)-4-PHENYLPIPERAZINE;1-(2-chloroethyl)-4-phenylpiperazine(SALTDATA: 2HCl)
• CAS NO: 43219-09-6
• Molecular Formula: C₁₂H₁₇ClN₂
• Molecular Weight: 224.73
• Mol File: 43219-09-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 334.2°C at 760 mmHg
• Flash Point: 155.9°C
• Appearance: /
• Density: 1.114g/cm³
• Vapor Pressure: 0.00013mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 1-(2-CHLOROETHYL)-4-PHENYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLOROETHYL)-4-PHENYLPIPERAZINE(43219-09-6)
• EPA Substance Registry System: 1-(2-CHLOROETHYL)-4-PHENYLPIPERAZINE(43219-09-6)

Safety Data

• Hazardous Substances Data: 43219-09-6(Hazardous Substances Data)

Usage

General Description

1-(2-chloroethyl)-4-phenylpiperazine is a chemical compound that belongs to the class of piperazine derivatives. It is a psychoactive substance that has been studied for its potential use as a pharmacological agent, particularly in the treatment of depression and anxiety disorders. The compound has been found to exhibit anxiolytic and anti-depressant properties in preclinical studies, and has also been investigated for its potential in the treatment of substance abuse disorders. Additionally, 1-(2-chloroethyl)-4-phenylpiperazine has been researched for its potential as a radiotracer for imaging serotonin receptors in the brain, which could have implications for the diagnosis and treatment of various psychiatric and neurological conditions. However, further research is needed to fully understand the therapeutic potential and safety profile of this compound.

InChI:InChI=1/C12H17ClN2/c13-6-7-14-8-10-15(11-9-14)12-4-2-1-3-5-12/h1-5H,6-11H2

Upstream product

• 4004-95-9 1-phenylpiperazine hydrochloride 
• 107-04-0 1-Bromo-2-chloroethane 
• 62-53-3 aniline 
• 75-21-8 oxirane 
• 92-54-6 4-phenyl-1-piperazine 
• 36245-26-8 1-(2-hydroxyethyl)-4-phenylpiperazine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 72223-83-7 1-[2-(4-benzyloxy-phenoxy)-ethyl]-4-phenyl-piperazine 
• 36134-35-7 7-methoxy-3-[2-(4-phenyl-piperazin-1-yl)-ethyl]-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 103072-76-0 N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carboxamide 
• 142714-59-8 1-<2-(4-phenyl-1-piperazinyl)ethyl>oxazolo<5,4-b>pyridin-2(1H)-one 

Relevant articles and documents

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Versatile synthesis of disubstituted triazole library for dopamine and serotonin receptor ligands

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Antidiabetic piperazine derivatives, processes for their preparation and compositions containing them

Piperazine derivatives of formula (I) wherein Z, X, n, Ar and i have the meanings defined herein are usefull in the treatment of pathologies associated with insulin-resistance syndrome.