4322-98-9

Upstream product

• 82153-11-5 2-Methanesulfinyl-N-(4-nitro-phenyl)-benzamide 
• 100-01-6 4-nitro-aniline 
• 4892-02-8 Methyl thiosalicylate 
• 147-93-3 Thiosalicylic acid 
• 3950-02-5 2-chlorosulfenylbenzoyl chloride 
• 82153-08-0 2-Methylsulfanyl-N-(4-nitro-phenyl)-benzamide 
• 1442-03-1 2-methylsulfanyl-benzoyl chloride 
• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 2527-64-2 2,2′-disulfanediylbis(N-(4-nitrophenyl)benzamide) 

Downstream Products

• 79958-33-1 2-(4-nitro-phenyl)-1,1-dioxo-1λ⁶-benz[d]isothiazol-3-one 

Relevant academic research and scientific papers

Facile synthesis and in vitro activity of n-substituted 1,2-benzisothiazol-3(2H)-ones against dengue virus NS2BNS3 protease

Several new N-substituted 1,2-benzisothiazol-3(2H)-ones (BITs) were synthesised through a facile synthetic route for testing their anti-dengue protease inhibition. Contrary to the conventional multistep synthesis, we achieved structurally diverse BITs with excellent yields using a two-step, one-pot reaction strategy. All the synthesised compounds were prescreened for drug-like properties using the online Swiss Absorption, Distribution, Metabolism and Elimination (SwissADME) model, indicating their favourable pharmaceutical properties. Thus, the synthesised BITs were tested for inhibitory activity against the recombinant dengue virus serotype-2 (DENV-2) NS2BNS3 protease. Dose–response experiments and computational docking analyses revealed that several BITs bind to the protease in the vicinity of the catalytic triad with IC50 values in the micromolar range. The DENV2 infection assay showed that two BITs, 2-(2-chlorophenyl)benzo[d]isothiazol-3(2H)-one and 2-(2,6-dichlorophenyl)benzo[d]isothiazol-3(2H)-one, could suppress DENV replication and virus infectivity. These results indicate the potential of BITs for developing new anti-dengue therapeutics.

Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis

An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.

Method for generating benzisothiazolinone compounds by catalyzing oxidization of molecular oxygen in aqueous phase

The invention provides a method for synthesizing benzisothiazolinone compounds by catalyzing oxidization of molecular oxygen in an aqueous phase. A water-soluble transition metal phthalocyanine compound is taken as a catalyst, and a thiosalicylic acid ami

An efficient approach to construct benzisothiazol-3(2: H)-ones via copper-catalyzed consecutive reaction of 2-halobenzamides and carbon disulfide

An efficient copper-catalyzed reaction for the synthesis of benzisothiazol-3(2H)-ones has been developed, starting from easily available 2-halobenzamides and carbon disulfide, which gave the corresponding target products in 30-89% yield for 25 examples. The reaction proceeds via a consecutive process with S-C bond and S-N bond formation.