43228-96-2

Basic information

• Product Name: 5-CHLORO-1-(2-METHOXYPHENYL)-1-OXOPENTANE
• Synonyms: 5-CHLORO-1-(2-METHOXYPHENYL)-1-OXOPENTANE
• CAS NO: 43228-96-2
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.7
• Mol File: 43228-96-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 342.118°C at 760 mmHg
• Flash Point: 138.631°C
• Appearance: /
• Density: 1.101g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: 5-CHLORO-1-(2-METHOXYPHENYL)-1-OXOPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1-(2-METHOXYPHENYL)-1-OXOPENTANE(43228-96-2)
• EPA Substance Registry System: 5-CHLORO-1-(2-METHOXYPHENYL)-1-OXOPENTANE(43228-96-2)

Safety Data

• Hazardous Substances Data: 43228-96-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15ClO2/c1-15-12-8-3-2-6-10(12)11(14)7-4-5-9-13/h2-3,6,8H,4-5,7,9H2,1H3

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 501083-58-5 5-chloro-1-(2-methoxyphenyl)-1-pentanol 

Downstream Products

• 501083-61-0 5-chloro-1-(2-hydroxyphenyl)-1-pentanone 

Relevant articles and documents

Synthesis and structure-affinity relationships of 1-[ω-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT7 receptor ligands

Structural requirements for 5-HT7 receptor affinity and selectivity over that for the 5-HT1A receptor were studied on a series of 1-[ω-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones. The presence of a hydroxy or methoxy substituent on aryl ketone moiety, alkyl chain length, and the nature of N-1-piperazine substituent were explored. 6-[4-(3-Benzisoxazolyl)-1-piperazinyl]-1-(2-hydroxyphenyl)-1-hexanone (40) and its methoxy analogue 43 exhibited high 5-HT7 receptor affinities (Ki = 2.93 nM and 0.90 nM, respectively) and agonist properties when tested for 5-HT7 receptor-mediated relaxation of substance P-induced guinea-pig ileum contraction.