4323-13-1Relevant academic research and scientific papers
Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases
-
Page/Page column 29, (2010/11/24)
The invention concerns pharmaceutical compositions that contain a compound or compounds that can effectively regulate the activity of Type 5 Adenylyl Cyclase and methods for treatment of neurological diseases and disorders, as well as motor function loss
Hydroxamate based inhibitors of adenylyl cyclase. Part 1: The effect of acyclic linkers on P-site binding
Levy, Daniel E,Marlowe, Charles,Kane-Maguire, Kim,Bao, Ming,Cherbavaz, Diana B.,Tomlinson, James E.,Sedlock, David M.,Scarborough, Robert M.
, p. 3085 - 3088 (2007/10/03)
The adenylyl cyclases (ACs) are a family of enzymes that are key elements of signal transduction by virtue of their ability to convert ATP to cAMP. The catalytic mechanism of this transformation proceeds through initial binding of ATP to the purine bindin
Polymethylene Derivatives of Nucleic Bases with ω-Functional Groups: II. Adenine and Hypoxanthine Derivatives
Makinsky,Kritzyn,Ul'yanova,Zakharova,Bugreev,Nevinsky
, p. 167 - 172 (2007/10/03)
N9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the ω-position of the alkyl substituent were synthesized. Their physicochemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.
