Cas 432503-80-5,(4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone

432503-80-5

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Basic information

Product Name: (4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone
Synonyms: (4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone
CAS NO:432503-80-5
Molecular Formula:
Molecular Weight: 277.323
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone(CAS DataBase Reference)
NIST Chemistry Reference: (4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone(432503-80-5)
EPA Substance Registry System: (4-ethylpiperazin-1-yl)(3-methyl-4-nitrophenyl)methanone(432503-80-5)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 432503-80-5(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 432503-80-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,2,5,0 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 432503-80:
(8*4)+(7*3)+(6*2)+(5*5)+(4*0)+(3*3)+(2*8)+(1*0)=115
115 % 10 = 5
So 432503-80-5 is a valid CAS Registry Number.

432503-80-5Upstream product

432503-80-5Downstream Products

1234562-95-8 C₁₉H₂₆N₄O₃

432503-80-5Relevant academic research and scientific papers

Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents

Kawada, Hatsuo,Ebiike, Hirosato,Tsukazaki, Masao,Yamamoto, Shun,Koyama, Kohei,Nakamura, Mitsuaki,Morikami, Kenji,Yoshinari, Kiyoshi,Yoshida, Miyuki,Ogawa, Kotaro,Shimma, Nobuo,Tsukuda, Takuo,Ohwada, Jun

, p. 2897 - 2906 (2016)

Phosphoinositide 3-kinase (PI3K) is a promising anti-cancer target, because various mutations and amplifications are observed in human tumors isolated from cancer patients. Our dihydropyrrolopyrimidine derivative with a phenylurea moiety showed strong PI3

Novel and potent 5-piperazinyl methyl- N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands

Nirogi, Ramakrishna V. S.,Kothmirkar, Prabhakar,Kambhampati, Ramasastri,Konda, Jagadish Babu,Arepalli, Sobhanadri,Pamuleti, Narasimhareddy G.,Deshpande, Amol D.,Bandyala, Trinathreddy,Shinde, Anil K.,Dubey

scheme or table, p. 340 - 344 (2010/11/18)

The exclusive distribution of 5-HT6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N1-aryl sulfonyl indoles were designed and synthesized as 5-HT6R ligands. Most of the synthesized compounds are potent when tested by in vitro radioligand binding assay. The lead compound from the series does not have the CYP liabilities and is active in an animal model of cognition.

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