433-48-7

Basic information

• Product Name: 3-fluoropyruvate
• Synonyms: 3-fluoropyruvate;3-Fluoropyruvic acid;2-Oxo-3-fluoropropionic acid;3-Fluoro-2-oxopropanoic acid;Fluoropyruvic acid
• CAS NO: 433-48-7
• Molecular Formula: C₃H₃FO₃
• Molecular Weight: 106.05
• Mol File: 433-48-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 174.9°Cat760mmHg
• Flash Point: 59.6°C
• Appearance: /
• Density: 1.409g/cm³
• Vapor Pressure: 0.566mmHg at 25°C
• CAS DataBase Reference: 3-fluoropyruvate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoropyruvate(433-48-7)
• EPA Substance Registry System: 3-fluoropyruvate(433-48-7)

Safety Data

• Hazardous Substances Data: 433-48-7(Hazardous Substances Data)

Usage

Uses

3-Fluoropyruvic Acid is a useful building block and has been proposed to have a mechanistic effect on the inactivation of mandelate racemase.

Definition

ChEBI: A pyruvic acid derivative having a 3-fluoro substituent.

InChI:InChI=1/C3H3FO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)/p-1

Upstream product

• 16652-37-2 3-fluoroalanine 
• 392-58-5 Diethyl fluoroxaloacetate 

Downstream Products

• 35455-20-0 (S)-3-fluoroalanine 
• 127-17-3 2-oxo-propionic acid 
• 35455-21-1 (R)-3-fluoroalanine 
• 35523-45-6 α-2H-β-19F-D-alanine 
• 16652-37-2 3-fluoroalanine 
• 51033-95-5 3-ethylthio-2-oxopropanoic acid 
• 401-48-9 Fluoropyruvic acid Semicarbazone 
• 399-87-1 fluoro-pyruvic acid methyl ester 

Relevant articles and documents

Kinetic resolution of 3-fluoroalanine using a fusion protein of D-amino acid oxidase with Vitroscilla hemoglobin

In this study, a fusion protein (VHb-DAAO) of D-amino acid oxidase (DAAO) with Vitreoscilla hemoglobin (VHb) was functionally expressed in Escherichia coli and purified. The kcat value VHb-DAAO (47.1 s-1) towards rac-3-flouroalanine was about 2-fold higher than that of DAAO (21.9 s -1). rac-3-Flouroalanine (500 mm) was kinetically resolved into (R)-3-fluoroalanine with high enatiomeric excess (>99%) by VHb-DAAO with about 52% conversion.

Stereoselectivities in Enzymatic Syntheses of Fluorocitric Acid

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