17α-Strophanthidin, also known as ouabain, is a potent cardiac glycoside derived from the seeds of the African Strophanthus gratus plant. It is a naturally occurring steroidal alkaloid that has been used for centuries in traditional medicine for its cardiotonic effects. 17α-Strophanthidin works by inhibiting the sodium-potassium ATPase enzyme, which is crucial for maintaining the electrochemical gradient across the cell membrane. This inhibition leads to an increase in intracellular calcium levels, enhancing the force of cardiac muscle contractions and improving cardiac output. Due to its strong effects, 17α-strophanthidin is used in the treatment of congestive heart failure and certain arrhythmias, but it must be administered with caution due to its narrow therapeutic index and potential for toxicity.
The CAS Registry Mumber 4331-85-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,3 and 1 respectively; the second part has 2 digits, 8 and 5 respectively. Calculate Digit Verification of CAS Registry Number 4331-85: (6*4)+(5*3)+(4*3)+(3*1)+(2*8)+(1*5)=75 75 % 10 = 5 So 4331-85-5 is a valid CAS Registry Number.