433228-70-7

Upstream product

• 629-05-0 n-octyne 
• 103-19-5 di(p-tolyl) disulfide 
• 39549-10-5 1-[(4-methylphenyl)sulfanyl]pyrrolidine-2,5-dione 

Downstream Products

• 1034014-69-1 (E)-1-p-tolylsulfanyl-1-octenyl diphenyldithiophosphinate 
• 1353899-20-3 1-fluoro-4-{2-hexyl-3-[(4-methylphenyl)thio]prop-2-enyl}benzene 
• 1353899-14-5 3-{(1E)-1-[(4-methylphenyl)thio]-2-phenyloct-1-enyl}cyclohexanone 
• 142572-49-4 1-methyl-4-(oct-1-yn-1-ylsulfonyl)benzene 
• 298693-16-0 1-methyl-4-(oct-1-yne-1-sulfinyl)-benzene 

Relevant academic research and scientific papers

Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio- and Stereoselective Synthesis of Trifluoromethoxylated Alkenes

The trifluoromethoxy group has elicited much interest among drug and agrochemical discovery teams because of its unique properties. We developed trifluoromethyl nonafluorobutanesulfonate (nonaflate), TFNf, an easy-to-handle, bench-stable, reactive, and scalable trifluoromethoxylating reagent. TFNf is easily and safely prepared in a simple process in large scale and the nonaflyl part of TFNf can easily be recovered as nonaflyl fluoride after usage and recycled. The synthetic potency of TFNf was showcased with the underexplored synthesis of various trifluoromethoxylated alkenes, through a high regio- and stereoselective hydro(halo)trifluoromethoxylation of alkyne derivatives such as haloalkynes, alkynyl esters, and alkynyl sulfones. The synthetic merits of TFNf were further underscored with a high-yielding and smooth nucleophilic trifluoromethoxylation of alkyl triflates/bromides and primary/secondary alcohols.

Stereoselective synthesis of polyfunctional tetrasubstituted alkenyl sulfides via a carbocupration of alkynyl sulfides with aryl and benzylic diorganozincs

A general method for the synthesis of tetrasubstituted alkenyl sulfides has been developed by the carbocupration of alkynyl sulfides with functionalized diorganozinc reagents in the presence of CuCN·2LiCl. The intermediate alkenylcopper reagents readily r

Regio- and stereoselective additions of diphenyldithiophosphinic acid to N-(1-alkynyl)amides and 1-alkynyl sulfides

Treatment of N-(l-alkynyl)amides and 1-alkynyl sulfides with diphenyldithiophosphinic acid affords (E)-ketene N,S-acetals and S.S-acetals, respectively. The addition reactions proceed in syn fashions, which consist of protonation of the electron-rich alkynes and the following nucleophilic addition of diphenyldithiophosphinate anion to the resulting cationic intermediates.