433289-84-0 Usage
Uses
Used in Pharmaceutical Industry:
Defluoro Atorvastatin is used as an impurity in the production of Atorvastatin for the treatment of hypercholesterolemia. Its presence is crucial for the effectiveness of Atorvastatin, as it helps in lowering both elevated LDL-cholesterol and triglycerides in patients, thus managing and preventing cardiovascular diseases.
Additionally, further research and development may explore the potential applications of Defluoro Atorvastatin in other areas of the pharmaceutical industry, such as drug delivery systems or as a standalone therapeutic agent, depending on its properties and interactions with other compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 433289-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,3,2,8 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 433289-84:
(8*4)+(7*3)+(6*3)+(5*2)+(4*8)+(3*9)+(2*8)+(1*4)=160
160 % 10 = 0
So 433289-84-0 is a valid CAS Registry Number.
433289-84-0Relevant academic research and scientific papers
Synthesis of some impurities and/or degradation products of atorvastatin
Stach, Jan,Havlicek, Jaroslav,Placek, Lukas,Radl, Stanislav
, p. 229 - 246 (2008/12/22)
Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl) pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)-and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
