4333-14-6Relevant academic research and scientific papers
Synthesis, characterization, DFT, docking studies and molecular dynamics of some 3-phenyl-5-furan isoxazole derivatives as anti-inflammatory and anti-ulcer agents
M, Pallavi H,Al-Ostoot, Fares Hezam,Vivek, Hamse Kameshwar,Khanum, Shaukath Ara
, (2021/11/17)
A vast number of nitrogen heterocyclic derivatives comprising oxygen atom is considered as a valuable combination of therapeutic agents in curative chemistry. In particular, isoxazole, a five-member heterocyclic ring, is detected along with some of the ma
Design, synthesis of novel furan appended benzothiazepine derivatives and in vitro biological evaluation as potent VRV-PL-8a and H+/K+ ATPase inhibitors
Lokeshwari, Devirammanahalli Mahadevaswamy,Rekha, Nanjappagowda Dharmappa,Srinivasan, Bharath,Vivek, Hamse Kameshwar,Kariyappa, Ajay Kumar
supporting information, p. 3048 - 3054 (2017/06/13)
A series of new of furan derivatised [1,4] benzothiazepine analogues were synthesized starting from 1-(furan-2-yl)ethanone. 1-(Furan-2-yl)ethanone was converted into chalcones by its reaction with various aromatic aldehydes, then were reacted with 2-amino
ALLOSTERIC INHIBITORS OF ATYPICAL PROTEIN KINASES C
-
Paragraph 0090; 0108; 0140, (2015/06/08)
The invention provides specific small molecule compounds that allosterically regulate the activity of atypical protein kinase C, their use as a medicament, and their use in the treatment and prevention of allergic, inflammatory and autoimmune disorders, cancer, hyperproliferation, sepsis, viral and protozoan infections, dementing diseases, metabolic, sclerotic and osteoporotic disorders.
Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-χ
Abdel-Halim, Mohammad,Diesel, Britta,Kiemer, Alexandra K.,Abadi, Ashraf H.,Hartmann, Rolf W.,Engel, Matthias
supporting information, p. 6513 - 6530 (2014/10/15)
There is increasing evidence that the atypical protein kinase C, PKCχ, might be a therapeutic target in pulmonary and hepatic inflammatory diseases. However, targeting the highly conserved ATP-binding pocket in the catalytic domain held little promise to
Synthesis of 1,5-benzothiazepines: Part 41: Single pot synthesis and antimicrobial studies of 8-substituted-2,5-dihydro-4-(4-substituted aryl)-2-(2-furyl)-1,5-benzothiazepines
Pant, Seema,Avinash,Yadav, Meenakshi
, p. 381 - 386 (2019/01/21)
8-Substittued-2,5-dihydro-4-(4-chlorophenyl/nitrophenyl)-2-(2-furyl)-1,5- benzothiazepines have been synthesized by the reaction of 5-substituted-2- aminobenzenethiols with αβ-unsaturated carbonyl compounds, such as 1-(4- chlorophenyl)-3-(2-furyl)-2-propenone and 3-(2-furyl)-1-(4-nitrophenyl)-2-propenone in dry ethanol saturated with dry HCl and in dry toluene containing trifluoroacetic acid respectively, in 52-65% yields. The products were characterized by microestimations for C,H and N and by spectral studies comprising IR, 1H NMR and mass spectral studies. All the synthesized compounds have been screened for their antimicrobial activity against Gram-positive bacteria, Staphylococcus aureus, Gram-negative bacteria, Pseudomonas aeruginosa and fungi, Candida albicans and Aspergillus niger. Most of the compounds exhibited good antifungal activity.
Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones
Nepali, Kunal,Kadian, Kanika,Ojha, Ritu,Dhiman, Rajni,Garg, Atul,Singh, Gagandip,Buddhiraja, Abhishek,Bedi, Preet Mohinder Singh,Dhar, Kanaya Lal
, p. 2990 - 2997 (2012/10/29)
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C6-C 3-C6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines. Springer Science+Business Media, LLC 2011.
A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4, 5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors
Nepali, Kunal,Singh, Gurinderdeep,Turan, Anil,Agarwal, Amit,Sapra, Sameer,Kumar, Raj,Banerjee, Uttam C.,Verma, Prabhakar K.,Satti, Naresh K.,Gupta, Manish K.,Suri, Om P.,Dhar
experimental part, p. 1950 - 1958 (2011/04/27)
Xanthine oxidase is a complex molybdoflavoprotein that catalyses the hydroxylation of xanthine to uric acid. Fifty three analogues of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles were rationally designed and synthesized and evaluated for in vitro xanthine
