433304-61-1

Basic information

• Product Name: 4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide
• Synonyms: 4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide
• CAS NO: 433304-61-1
• Molecular Weight: 746.719
• Mol File: 433304-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide(433304-61-1)
• EPA Substance Registry System: 4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide(433304-61-1)

Safety Data

• Hazardous Substances Data: 433304-61-1(Hazardous Substances Data)

Upstream product

• 28863-62-9 (3,3-dimethyl-2,4-dioxacyclopentyl)methyl chloroformate 
• 33419-42-0 etoposide 

Relevant articles and documents

Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs.

Two 4'-propylcarbonoxy derivatives (2,3) of etoposide (1), a topoisomerase II inhibitor, were synthesized and evaluated as potential prodrugs for anticancer therapy. Their activation via hydrolysis mechanisms was determined as a function of pH in buffer solutions, in human serum and in the presence of carboxyl ester hydrolase. Cytotoxicity was determined on various tumor cell lines and compared to the parent compound. On cell lines exhibiting resistance to etoposide we observed an enhanced cytotoxicity of the prodrugs of up to three orders of magnitude.