433313-55-4Relevant academic research and scientific papers
Mechanochemical synthesis of ethyl 4-(3-aryl-1-phenyl-1H-pyrazol-4- yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydro-pyrimidine-5- carboxylates and their antimicrobial activity
Sarasija,Ashok,Sudershan,Shivaraj
, p. 349 - 352 (2019/01/21)
An efficient and greener approach has been described for the synthesis of ethyl 4- (3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidine-5- carboxylates by multicomponent reaction of 3-aryl-1-phenyl-1H-pyrazole-4- carboxalde
Novel dihydropyrimidines as a potential new class of antitubercular agents
Trivedi, Amit R.,Bhuva, Vimal R.,Dholariya, Bipin H.,Dodiya, Dipti K.,Kataria, Vipul B.,Shah, Viresh H.
supporting information; experimental part, p. 6100 - 6102 (2010/11/18)
A small library of 30 dihydropyrimidines was synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H 37Rv. Two compounds, ethyl 4-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol- 4-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5 carboxylate 4a and ethyl 4-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-methyl-2-oxo-1,2,3, 4-tetrahydropyrimidine-5-carboxylate 4d were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent than isoniazid.
