433332-83-3Relevant academic research and scientific papers
Thermochemiluminescence as a fast method to detect and characterize hydroperoxide moieties in novel 3-hydroperoxyisothiazole 1,1-dioxides
Gilbert, Matthias,Zakharova, Valeria,Ramenda, Anna,Jebsen, Christian,Schulze, B?rbel,Wilhelm, Christian
body text, p. 6765 - 6771 (2012/08/28)
Hydroperoxy compounds are important for selective oxidation of organic precursors in the chemical industry. Moreover, novel 3-hydroperoxyisothiazole 1,1-dioxides (N-phthalimidyl sultams) have been shown to be potent and specific inhibitors of acetylcholinesterase (AChE) an important enzyme in the neurotransmitter process. The inhibitory potential of these novel compounds is clearly linked to the hydroperoxide moiety. Hydroperoxides are known for their chemi- and thermochemiluminescent reactivity. In this study we tested thermochemiluminescence (TCL) as a fast method to detect and characterize the hydroperoxide moiety in structurally different synthetic organic hydroperoxides.
Synthesis of monocyclic hydroperoxy- and hydroxy-substituted sulfin- and sulfonamides by oxidation of 4,5-dimethylisothiazolium salts
Taubert, Kathleen,Sieler, Joachim,Hennig, Lothar,Findeisen, Matthias,Schulze, Baerbel
, p. 183 - 195 (2007/10/03)
The isothiazolium salts 10, easily accessible by cyclocondensation of the thiocyanates 8 with the anilines 9, yielded with H2O2 as the oxidant the first stable hydroperoxides of the 2-aryl-2,3-dihydroisothiazole 1-oxides rac-cis-13, the 1,1-dioxides 15, and their reduced 3-hydroxy derivatives rac-cis-14 and 16, respectively. The oxidation of 10 to new isothiazol-3(2H)-one 1,1-dioxides (17) is also described. For the first time, an aryl-bridged bis[isothiazolium salt] 11 was synthesized and oxidized.
