433701-34-9Relevant academic research and scientific papers
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer
Lin, Shu-Yu,Chang Hsu, Yung,Peng, Yi-Hui,Ke, Yi-Yu,Lin, Wen-Hsing,Sun, Hsu-Yi,Shiao, Hui-Yi,Kuo, Fu-Ming,Chen, Pei-Yi,Lien, Tzu-Wen,Chen, Chun-Hwa,Chu, Chang-Ying,Wang, Sing-Yi,Yeh, Kai-Chia,Chen, Ching-Ping,Hsu, Tsu-An,Wu, Su-Ying,Yeh, Teng-Kuang,Chen, Chiung-Tong,Hsieh, Hsing-Pang
supporting information, p. 10108 - 10123 (2019/11/29)
Epidermal growth factor receptor (EGFR)-targeted therapy in non-small cell lung cancer represents a breakthrough in the field of precision medicine. Previously, we have identified a lead compound, furanopyrimidine 2, which contains a (S)-2-phenylglycinol
Synthesis and biological evaluation of 3-methyl-5-phenylthieno[2,3-d]-pyrimidine-2,4(1 H,3H)-dione derivatives for the treatment of diet-induced obesity
Sang, Yun,Pei, Heyin,Ma, Liang,Huang, Li,Xie, Caifeng,Chen, Jinying,Liang, Xiaolin,Ran, Yan,Wang, Guangcheng,Yang, Zhuang,Cao, Dong,He, Lin,Wu, Yuzhe,He, Linhong,Zhu, Jun,Lan, Jingbo,Chen, Lijuan
, p. 883 - 891 (2014/12/12)
Triglycerides are the main part of fats and half of the lipids in hepatocytes, and play an important role in metabolism as energy sources and transporters of dietary fat. In this study, 33 derivatives based on 3-methyl-5-phenylthieno[2,3-d]pyrimidine-2,4(
2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation
Zhu, Jin,Chen, Tong,Liu, Jie,Ruoqun, Ma.,Lu, Weiqiang,Huang, Jin,Li, Honglin,Li, Jian,Jiang, Hualiang
experimental part, p. 785 - 797 (2009/05/27)
The cysteine protease falcipain-2 (FP-2) of Plasmodium falciparum is a principal cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites, making it become an attractive target enzyme for developing anti-malarial drugs.
Aryl alkyl ketones in a one-pot Gewald synthesis of 2-aminothiophenes
Tormyshev, Victor M.,Trukhin, Dmitry V.,Rogozhnikova, Olga Yu.,Mikhalina, Tatiana V.,Troitskaya, Tatiana I.,Flinn, Anthony
, p. 2559 - 2564 (2008/09/16)
2-Aminothiophene-3-carboxylates bearing various aryl groups at the 4-position are readily obtained in good to moderate yields by the one-pot Gewald reaction of aryl alkyl ketones with ethyl cyanoacetate and elemental sulfur in the presence of morpholinium acetate and excess morpholine. Georg Thieme Verlag Stuttgart.
THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
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Page/Page column 66-67, (2008/06/13)
Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are d
