433958-49-7

Upstream product

• 31165-67-0 2'-benzyloxyacetophenone 
• 109-77-3 malononitrile 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 

Downstream Products

• 433959-24-1 N-[5-[2-amino-6-(2-benzyloxyphenyl)-3-cyano-4-pyridinyl]-2-(1-pyrrolidinyl) phenyl]-3-(1-piperidinyl)propanamide 
• 643021-69-6 N-{5-[2-amino-6-(2-benzyloxy-phenyl)-3-cyano-pyridin-4-yl]-2-dimethylamino-phenyl}-3-piperidin-1-yl-propionamide 
• 433958-48-6 2-amino-4-[3-amino-4-(1-pyrrolidinyl)phenyl]-6-(2-benzyloxyphenyl)nicotinonitrile 
• 643021-72-1 2-amino-4-(3-amino-4-dimethylamino-phenyl)-6-(2-benzyloxy-phenyl)-nicotinonitrile 
• 553635-46-4 2-amino-6-(2-benzyloxy-phenyl)-4-(4-dimethylamino-3-nitro-phenyl)-nicotinonitrile 
• 433958-50-0 2-amino-6-(2-benzyloxyphenyl)-4-[3-nitro-4-(1-pyrrolidinyl)phenyl]nicotinonitrile 

Relevant academic research and scientific papers

4-6-Diphenyl pyridine derivatives as antiinflammatory agents

4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6 alkyl, etc.; R4 is hydrogen, hydroxy, halogen, amino, etc.; R5

Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1

IκB kinase β (IKK-β) is a serine-threonine protein kinase critically involved in the activation of the transcription factor Nuclear Factor kappa B (NF-κB) in response to various inflammatory stimuli. We have identified a small molecule inhibitor of IKK-β. Optimization of the lead compound resulted in improvements in both in vitro and in vivo potency, and provided IKK-β inhibitors exhibiting potent activity in an acute cytokine release model (LPS-induced TNFα).