4342-43-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-cyclohexylamine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, enhancing their efficacy and safety.
Used in Agrochemical Industry:
2-Methoxy-cyclohexylamine is utilized as an intermediate in the production of agrochemicals, where it plays a role in the synthesis of compounds that can protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Medical Research:
2-Methoxy-cyclohexylamine is used as a subject of study in medical research for its potential therapeutic applications. It has been investigated for its potential in treating conditions such as epilepsy and depression, due to its interaction with neurological pathways and neurotransmitters.
Used in Neuroprotective Therapy:
2-Methoxy-cyclohexylamine is considered for its neuroprotective properties, making it a candidate for research into treatments for neurodegenerative diseases. Its potential to protect neurons and mitigate disease progression is of significant interest to scientists in the field of neurology.
Environmental Consideration:
2-Methoxy-cyclohexylamine is noted for its low toxicity, which reduces the risk of adverse health effects for humans and animals. Additionally, it is not recognized as a significant environmental pollutant, indicating that its use is less likely to contribute to environmental contamination.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 6850-38-0 2-aminocyclohexanol 
• 91-23-6 2-Nitroanisole 
• 7429-44-9 2-methoxycyclohexanone 
• 93-26-5 2-methoxyacetanilide 

Downstream Products

• 1424464-11-8 1-(3-fluoro-4-hydroxy-benzyl)-3-(2-methoxy-cyclohexyl)-urea 

Relevant academic research and scientific papers

Highly efficient one-pot multi-directional selective hydrogenation and N-alkylation catalyzed by Ru/LDH under mild conditions

Atomic economy, non-toxicity, harmlessness and multidirectional selectivity advocated by green chemistry have increasingly become a hot and difficult research topic. Herein, we present a highly efficient, one-pot tandem and easy-to-operate method through which we could directly produce a broad range of multi-directional selective hydrogenated amines or N-alkyl aliphatic amines using aromatic nitro compounds as raw materials. Ru/LDH with characteristics of layered mesoporous structure, well dispersed small Ru nanoparticles and LDH stabilization to the Ru NPs was employed as the catalyst. It is remarkable that multi-directional superb chemoselectivity to aromatic amines, alicyclic amines as well as N-alkyl aliphatic amines could be achieved with excellent catalytic activity and recyclability by tuning reaction conditions over 5wt%Ru/LDH-2. Additionally, this catalytic system also exhibited attractive activity and multi-directional chemoselectivity in the hydrogenation of quinoline and its derivatives with solvents of different polarity. Chemoselectivity to 5,6,7,8-tetrahydroquinoline derivatives could reach as high as 95.6 %.

Method for preparing amino ether compounds

The invention belongs to the technical field of organic synthesis and relates to a method for preparing amino ether compounds. The method comprises the following steps: by taking amino alcohol as a raw material, protecting amino in the amino alcohol so as to obtain Schiff base; carrying out an etherification reaction on the hydroxyl group in the Schiff base; and finally, performing amino deprotection, thereby obtaining corresponding amino ethers. The method disclosed by the invention has high regio-selectivity, the substrates of higher than 99.9% are subjected to etherification reaction, the reaction conversion ratio of each step is higher than 99.8%, and the total yield is higher than 95%; when amino alcohol is chiral, the amino ethers with retention of configuration can be obtained; and moreover, each step of the method is a conventional operation, the process cost is low, and three wastes are few, the energy consumption is low, an environment-friendly effect is achieved, and large-scale industrial production is easily realized.

Asymmetric Reductive Amination of Ketones Catalyzed by Imine Reductases

Biocatalysis employing imine reductases is a promising approach for the one-step generation of chiral amines from ketones. The enzymes reported for this process suffer from low activity and moderate stereoselectivity. We identified a set of enzymes that facilitate this reaction with high to quantitative conversions from a library of 28 imine reductases. This enabled the conversion of ketones with ammonia, methylamine, or butylamine into the corresponding amines. Most importantly, we performed preparative (>100 mg) scale syntheses of amines such as (1S,3R)-N,3-dimethylcyclohexylamine and (R)-N-methyl-2-aminohexane with excellent stereochemical purities (98 % de, 96 % ee) in good yields.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.