434307-26-3

Basic information

• Product Name: [(R)-Cyclopropyl(phenyl)methyl]amine
• Synonyms: [(R)-Cyclopropyl(phenyl)methyl]amine;(1R)CYCLOPROPYLPHENYLMETHYLAMINE-HCl;(1R)-CyclopropylphenylMethylaMine hydrochloride;(R)-C-Cyclopropyl-C-phenyl-methylamine
• CAS NO: 434307-26-3
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Mol File: 434307-26-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 234.7 °C at 760 mmHg
• Flash Point: 98.4 °C
• Appearance: /
• Density: 1.082
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: [(R)-Cyclopropyl(phenyl)methyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-Cyclopropyl(phenyl)methyl]amine(434307-26-3)
• EPA Substance Registry System: [(R)-Cyclopropyl(phenyl)methyl]amine(434307-26-3)

Safety Data

• Hazardous Substances Data: 434307-26-3(Hazardous Substances Data)

Usage

General Description

[(R)-Cyclopropyl(phenyl)methyl]amine is a chemical compound with the molecular formula C11H13N. It is an amine derivative, with a cyclopropyl-phenyl-methyl group attached to the amine functional group. [(R)-Cyclopropyl(phenyl)methyl]amine is chiral, with a single stereocenter, and exists as a pair of enantiomers. It is used as a building block in organic synthesis and has been studied for its potential pharmaceutical applications.[(R)-Cyclopropyl(phenyl)methyl]amine may have a range of potential biological activities, including as an antitumor agent, a pesticide, and as a potential treatment for alcohol abuse. It is important to handle and use this compound with proper safety precautions, as it can be hazardous if not handled properly.

Relevant articles and documents

Method for synthesizing chiral amine compound

The present invention provides a method for synthesizing a chiral amine compound. The method comprises the following steps: (1) reacting a compound of formula I with t-butylsulfonamide in the presenceof a catalyst to obtain a compound having a structure represented by formula II; 2) reacting the compound of the formula II in a hydrogen atmosphere in the presence of an iridium catalyst and a ligand to obtain a compound of formula III; and (3) carrying out a t-butylsulfonyl group removal reaction on the compound of the formula III to obtain the chiral amine compound. The method constructs the structure of sulfonamide by a keto carbonylgroup, and synthesizes the chiral amine compound with the aralkylamine structure by an asymmetric catalytic hydrogenation reaction of the sulfonamide structure, the ee value is generally 80% or above, the highest ee value is 99% or above, the yield of each step reaction can reach 90% or above, and the total yield is high.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.