434898-73-4

Upstream product

• 59684-34-3 furandiol 
• 159012-54-1 (4S,5R)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 
• 434898-41-6 methyl (4S,5R)-3-(benzyloxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylate 
• 158810-74-3 (-)-(2R,3S)-methyl 3-(benzyloxycarbonylamino)-2-hydroxy-3-phenylpropanoate 
• 132201-32-2 (2R,3S)-3-phenylisoserine hydrochloride 

Relevant academic research and scientific papers

Synthesis and Antifeedant Properties of N-Acylphenylisoserinates of Lactarius Sesquiterpenoid Alcohols

The esterification of various sesquiterpenoid alcohols of Lactarius origin with N-benzoyl-[2R,3S]-phenylisoserine (side chain of Taxol), N-acetyl-[2R,3S]-phenylisoserine and N-tert-butoxy-[2R,3S]-phenylisoserine (side chain of Taxotere) produced compounds whose antifeedant properties against storage pests Tribolium confusum, Trogoderma granarium, Sitophylus granarius and Rhizoperta dominica were measured. The introduction of the ester moiety in these molecules, in comparison to original compounds, moderately enhanced their antifeedant activities, as well as changed their selectivity of activity towards the test insects.

Synthesis of N-Acetyl-3-phenylisoserinates of sesquiterpenoid alcohols of Lactarius origin

Important biological properties of Taxol i.e. 13-N-benzoyl-(2R,3S)-3-phenylisoserinate of baccatin III and also N-benzoyl-(2R,3S)-3-phenylisoserinates of several sesquiterpenoid alcohols of Lactarius origin prompted us to synthesize N-acetyl-3-phenylisose