434937-46-9Relevant academic research and scientific papers
Alkoxy-5-nitrosopyrimidines: Useful building block for the generation of biologically active compounds
Marchal, Antonio,Nogueras, Manuel,Sanchez, Adolfo,Low, John N.,Naesens, Lieve,De Clercq, Erik,Melguizo, Manuel
supporting information; experimental part, p. 3823 - 3830 (2010/10/04)
Several alkoxy-5-nitrosopyrimidines were synthesised and high regioselective and sequential nucleophilic aromatic substitution of methoxy groups in 2-am:ino-4,6-d.imetho;xy-5nitrosopyrimidine was observed. The approach was applied to the synthesis of valu
Novel procedure for selective C-nitrosation of aminopyrimidine derivatives under neutral conditions. Scope and synthetic applications
Marchal, Antonio,Melguizo, Manuel,Nogueras, Manuel,Sánchez, Adolfo,Low, John N.
, p. 255 - 258 (2007/10/03)
A novel simple method, based on treatment with isoamyl nitrite (IAN) in DMSO without any added acid, to produce selective C(5)-nitrosation of aminopyrimidine derivatives is described. It proved to be suitable for a multigram scale and applicable to a larger range of pyrimidine derivatives, including amino-dialkoxypyrimidines, than the procedures previously known. Its scope is analyzed and some example on the usefulness of the newly prepared substances as intermediates in the synthesis of fused heterobicyclic derivatives of potential biological interest is presented.
2-amino-4,6-bis(benzyloxy)-5-nitroso-pyrimidine: Chains built from three-centre N-H...(N,O) and N-H...π(arene) hydrogen bonds
Quesada, Antonio,Low, John N.,Melguizo, Manuel,Nogueras, Manuel,Glidewell, Christopher
, p. o355-o358 (2007/10/03)
The molecules of the title compound, C18H16N4O3, exhibit a very polarized molecular-electronic structure. The molecules are linked into chains by a combination of an asymmetric three-centre N-H...(N,O) hydrogen
