434938-25-7

Upstream product

• 294198-50-8 2,2,2-trichloroethyl (4R,5S)-4-benzyloxy-5-hydroxy-2(E)-hexenoate 
• 434938-24-6 (E)-(4R,5S)-4-Benzyloxy-5-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-butyryloxy]-hex-2-enoic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 434938-26-8 (E)-(4R,5S)-4-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-hex-2-enoic acid (S)-2-[(E)-(1S,2R)-2-benzyloxy-1-methyl-4-(2,2,2-trichloro-ethoxycarbonyl)-but-3-enyloxycarbonyl]-1-methyl-ethyl ester 
• 455934-62-0 (E)-(4R,5S)-4-Benzyloxy-5-{(S)-3-[(E)-(S)-5-(tert-butyl-dimethyl-silanyloxy)-hex-2-enoyloxy]-butyryloxy}-hex-2-enoic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

Formal total synthesis of macrosphelide (+)-A, effect on macrolactonization depended upon the lactone formation position

Formal total synthesis of (+)-macrosphelide A (1) was achieved based on macrolactonization via path B from a seco-acid (3) and path C from a seco-acid (4). The yield of macrolactonization via paths B and C were 18 and 59%, respectively.