4351-48-8

Usage

Uses

Used in Pharmaceutical Industry:
9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate is used as a vasoconstrictor and anti-inflammatory agent for the treatment of various skin conditions, such as eczema, psoriasis, and dermatitis. Its vasoconstrictor activity helps to reduce skin inflammation and redness, while its anti-inflammatory properties help to alleviate itching, swelling, and pain associated with these conditions.

Relevant academic research and scientific papers

Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein

21-Desoxy-17α-acyloxy-20-keto-4-pregnenes having physiological properties are prepared by the reaction of a 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester or a 21-iodo-21-desoxy-17α-acyloxy-20-keto-4-pregnene with an iodide reagent selected from the group consisting of triphenylsilyl iodide, tri-lower alkylsilyl iodide and triphenylmethyl iodide. When said 17α,21-dihydroxy-20-keto-4-pregnene 17α,21-orthoester is reacted with less than two molar equivalents of a tri-lower alkylsilyl iodide reagent there is also formed a 21-iodo-21-desoxy-17-α -acyloxy-20-keto-4-pregnene, a useful intermediate, which, upon reaction with additional iodide reagent, is converted to the corresponding 21-desoxy-17α-acyloxy-20-keto-4-pregnene.