435293-68-8Relevant academic research and scientific papers
Nucleophilic addition of phenol derivatives to methyl 1- nitrocyclopropanecarboxylates
Lifchits, Olga,Alberico, Dino,Zakharian, Irina,Charette, Andre B.
, p. 6838 - 6840 (2008/12/22)
(Chemical Equation Presented) Nucleophilic ring opening of methyl 1-nitrocyclopropane-carboxylates by phenol derivatives in the presence of Cs2CO3 is described. The reaction tolerates a variety of substituents on both the aromatic alcohol and the cyclopropane and affords the products in good yields (53-84%) and with complete preservation of the enantiomeric excess at C-4. The methodology was applied in an enantioselective synthesis of the norepinephrine reuptake inhibitor atomoxetine (Strattera).
